Results 41 to 50 of about 280,308 (219)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

How do changes in flow magnitude due to hydroelectric power production affect fish abundance and diversity in temperate regions? A systematic review protocol

Environmental Evidence, 2020
Background Natural flow regimes are an essential component of healthy fluvial systems, but hydropower production alters flow components, disrupting natural processes and impacting species reliant on them.
Meagan Harper, Trina Rytwinski, Jessica J. Taylor, Joseph R. Bennett, Karen E. Smokorowski, Steven J. Cooke   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

What is the effect of prescribed burning in temperate and boreal forest on biodiversity, beyond pyrophilous and saproxylic species? A systematic review

Environmental Evidence, 2018
Background While the effects of prescribed burning on tree regeneration and on pyrophilous and/or saproxylic species are relatively well known, effects on other organisms are less clear.
Jacqualyn Eales, Neal R. Haddaway, Claes Bernes, Steven J. Cooke, Bengt Gunnar Jonsson, Jari Kouki, Gillian Petrokofsky, Jessica J. Taylor   +7 more
doaj   +1 more source

Assessing diverse evidence to improve conservation decision‐making

Conservation Science and Practice, 2023
Meeting the urgent need to protect and restore ecosystems requires effective decision‐making through wisely considering a range of evidence. However, weighing and assessing evidence to make complex decisions is challenging, particularly when evidence is ...
Alec P. Christie, William H. Morgan, Nick Salafsky, Thomas B. White, Robyn Irvine, Nicolas Boenisch, Rafael M. Chiaravalloti, Kate Kincaid, Ali Mohammad Rezaie, Hiromi Yamashita, William J. Sutherland   +10 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

ROSES RepOrting standards for Systematic Evidence Syntheses: pro forma, flow-diagram and descriptive summary of the plan and conduct of environmental systematic reviews and systematic maps

Environmental Evidence, 2018
Reliable synthesis of the various rapidly expanding bodies of evidence is vital for the process of evidence-informed decision-making in environmental policy, practice and research.
Neal R. Haddaway, Biljana Macura, Paul Whaley, Andrew S. Pullin   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Manipulating ungulate herbivory in temperate and boreal forests: effects on vegetation and invertebrates. A systematic review

Environmental Evidence, 2018
Background Livestock grazing and ‘overabundance’ of large wild herbivores in forested areas have long been perceived as conflicting with the aims of both silviculture and forest conservation; however, certain kinds of herbivory can help to maintain ...
Claes Bernes, Biljana Macura, Bengt Gunnar Jonsson, Kaisa Junninen, Jörg Müller, Jennie Sandström, Asko Lõhmus, Ellen Macdonald   +7 more
doaj   +1 more source