Results 131 to 140 of about 172,980,963 (238)

Strategies for Managing Fluids and Electrolytes in High-Output Stomas: A Systematic Review and Evidence Summary

Journal of Multidisciplinary Healthcare
Anna Wen,1,* Yanxia Jiao,2,* Ning Wang,2 Jie Xu,1 Xinyue Xu,1 Li Du,1 Lin Lv3 1Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Wound and Ostomy Care Center, Outpatient ...
Wen A, Jiao Y, Wang N, Xu J, Xu X, Du L, Lv L   +6 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

[Evidence synthesis: evidence-based clinical practice guidelines for monitoring at-risk newbornsSíntese de evidência: diretrizes de prática clínica baseada em evidência para o acompanhamento de recém-nascidos em risco]. [PDF]

Rev Panam Salud Publica, 2021
Organización Panamericana de la Salud.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study

BMC Psychiatry
Objectives To examine the prevalence of comorbidities and the use of psychiatric comedication among individuals in medical treatment for attention deficit hyperactivity disorder (ADHD), in comparison to a matched control group from the general population.
Maria Vestergaard, Rikke Faergemann Hansen, Per Hove Thomsen, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Leg ulcer management : enabling evidence-based practice

The treatment and care of patients suffering from Venous Leg Ulceration (VLU) constitutes a significant portion of wound care delivered in the UK. Despite the abundance of empirical evidence in this field, across the UK there is considerable variation in
Robinson, Hollie, Atkin, Leanne, Phillips, Kelly   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Psychometric Evaluation of the HIV Knowledge Questionnaire-18 in a Black Canadian Population

HIV/AIDS: Research and Palliative Care
Agatha Nyambi,1 Elizabeth Alvarez,1 Laura N Anderson,1 Fatimah Jackson-Best,1 Wangari Tharao,2 Egbe B Etowa,3 Shamara Baidoobonso,4 Maureen Owino,5 Pascal Djiadeu,1 Daeria O Lawson,1 Lawrence Mbuagbaw1,6– 10 1Department of Health Research Methods ...
Nyambi A, Alvarez E, Anderson LN, Jackson-Best F, Tharao W, Etowa EB, Baidoobonso S, Owino M, Djiadeu P, Lawson DO, Mbuagbaw L   +10 more
doaj