Results 71 to 80 of about 27,518 (251)

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Unilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.
Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan   +7 more
wiley   +1 more source

Early and Extensive Degeneration of Sensory Neurons in Spinocerebellar Ataxia Type 3

Movement Disorders, EarlyView.
Abstract Background Postmortem studies have shown significant degeneration of the peripheral nervous system (PNS) in spinocerebellar ataxia type 3 (SCA3). Although PNS involvement accelerates overall ataxia progression, PNS biomarkers for therapeutic trials are lacking and our mechanistic understanding of related clinical manifestations remains ...
Milou Baarsma, Bart P.C. van de Warrenburg, Nens van Alfen, Roderick P.P.W.M. Maas   +3 more
wiley   +1 more source

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source

Regenerative Peripheral Nerve Interface (RPNI) Surgery for Naturalistic Prosthetic Control

Muscle &Nerve, EarlyView.
ABSTRACT Loss of limb function remains a significant public health challenge affecting millions of people worldwide, causing high rates of disability, unemployment, and chronic pain. Current neuroprosthetic devices are limited by unintuitive control and poor long‐term embodiment.
Ahneesh J. Mohanty, Yucheng Tian, Theodore A. Kung, Cynthia A. Chestek, Alex K. Vaskov, Deanna H. Gates, Alison K. Snyder‐Warwick, Paul S. Cederna   +7 more
wiley   +1 more source

Influence of Vitamin B12 Deficiency on Auditory and Vestibular Functioning: An Objective Test‐Based Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the effectiveness of objective audiological and vestibular assessments in detecting functional changes associated with vitamin B12 deficiency. Data Sources A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and EMBASE databases.
Nesmah Zainab, Santhosh Periyasamy, Kishan Madikeri Mohan   +2 more
wiley   +1 more source

Empathy as ontological orientation: Embodiment, therapeutic presence and mirror‐touch synaesthesia

British Journal of Psychotherapy, EarlyView.
Abstract Empathy is widely regarded as a foundational element of effective psychotherapy and is routinely framed as a core clinical skill within training and accreditation frameworks. Despite this consensus, persistent conceptual and experiential tensions remain regarding whether empathy can genuinely be taught or whether it reflects a deeper ...
Nikolaos Souvlakis
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Evaluation of Intraoperative Somatosensory Evoked Potentials During Spine Surgery for Scoliosis

The Iraqi Journal of Medical Sciences
Background:    In scoliosis surgery, intraoperative somatosensory evoked potential (SSEP) monitoring has reduced the incidence of postoperative neurologic deficits.
Amrah M. Khudhur, Ali F. Al-Hashimi, Mohammed U. Umara   +2 more
doaj   +3 more sources