Results 61 to 70 of about 356,019 (243)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Laserocarpum, a new genus of Apiaceae endemic to Greece

Acta Societatis Botanicorum Poloniae, 2019
Laserpitium pseudomeum is an endemic umbellifer of Greece occurring in the mountains of Sterea Ellas and northern Peloponnese. Molecular data indicate that it is not related to its putative congeners, but instead constitutes an isolated lineage.
Krzysztof Spalik, Aneta Wojewódzka, Theophanis Constantinidis, Stephen R. Downie, Michał Gierek, Łukasz Banasiak   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Inside-out versus Upside-down: The Origin and Evolution of Metallicity Radial Gradients in FIRE Simulations of Milky Way-mass Galaxies and the Essential Role of Gas Mixing

The Astrophysical Journal
Within the Milky Way (MW), younger stellar populations exhibit steeper (more negative) metallicity radial gradients; the origin of this trend remains debated. The FIRE-2 cosmological simulations of MW-mass galaxies show the same trend as the MW, which in
Russell L. Graf, Andrew Wetzel, Jeremy Bailin, Matthew E. Orr   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Bacterial symbionts support larval sap feeding and adult folivory in (semi-)aquatic reed beetles

Nature Communications, 2020
Symbiotic microbes in insects can enable their hosts to access untapped nutritional resources. Here, the authors show that symbiotic bacteria in reed beetles can provide essential amino acids to sap-feeding larvae and help leaf-feeding adults to degrade ...
Frank Reis, Roy Kirsch, Yannick Pauchet, Eugen Bauer, Lisa Carolin Bilz, Kayoko Fukumori, Takema Fukatsu, Gregor Kölsch, Martin Kaltenpoth   +8 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Neuropeptidergic Systems in Pluteus Larvae of the Sea Urchin Strongylocentrotus purpuratus: Neurochemical Complexity in a “Simple” Nervous System

Frontiers in Endocrinology, 2018
The nervous system of the free-living planktonic larvae of sea urchins is relatively “simple,” but sufficiently complex to enable sensing of the environment and control of swimming and feeding behaviors.
Natalie J. Wood, Teresa Mattiello, Teresa Mattiello, Matthew L. Rowe, Matthew L. Rowe, Lizzy Ward, Lizzy Ward, Margherita Perillo, Maria Ina Arnone, Maurice R. Elphick, Paola Oliveri   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Searching for lost nucleotides of the pre-RNA World with a self-refining model of early Earth

Nature Communications, 2018
The nucleotides of RNA appear to be products of evolution. Experimental studies are showing that plausible proto-nucleotides can be formed in simulated early Earth environments.
Nicholas V. Hud
doaj   +1 more source