Results 61 to 70 of about 7,622,829 (352)

Chemical evolution with radial mixing [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2009
22 pages, 21 figures, 1 table updated to new GCS data release, slightly revised, accepted by ...
Schönrich, R, Binney, J
openaire   +7 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe

open access: yesMicrobial Cell, 2017
Prions are protein-based infectious entities associated with fatal brain diseases in animals, but also modify a range of host-cell phenotypes in the budding yeast, Saccharomyces cerevisiae. Many questions remain about the evolution and biology of prions.
Theodora Sideri   +6 more
doaj   +1 more source

Chemical Evolution Tomorrow [PDF]

open access: yes, 2002
The solar system is just one sample, though of course the most thoroughly studied sample, of cosmic chemistry. Some perspective on it can be gained from an overview of the chemical evolution of the Galaxy and Universe, how our knowledge of this evolution has developed, and what problems remain to be solved.
Virginia Trimble, Virginia Trimble
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

Refueling the Magic Furnace: Kilonova 2017 Rewrites the Story of Element Origins

open access: yesJournal of Big History, 2018
For more than half a century, we have understood element creation in the stars—described in Marcus Chown’s colorful image as “the magic furnace.” From 1958 until 2017, supernova explosions were thought to be the primary site of element creation above ...
Barry Woods
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia)

open access: yesBMC Plant Biology, 2017
Background Terpene rich leaves are a characteristic of Myrtaceae. There is significant qualitative variation in the terpene profile of plants within a single species, which is observable as “chemotypes”.
Amanda Padovan   +8 more
doaj   +1 more source

Transcriptional and proteomic analysis of the innate immune response to microbial stimuli in a model invertebrate chordate

open access: yesFrontiers in Immunology, 2023
Inflammatory response triggered by innate immunity can act to protect against microorganisms that behave as pathogens, with the aim to restore the homeostatic state between host and beneficial microbes.
Assunta Liberti   +10 more
doaj   +1 more source

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