Results 71 to 80 of about 477,042 (311)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Astrophysical JournalGas-phase metallicity gradients are a crucial element in understanding the chemical evolution of galaxies. We use the FOGGIE simulations to study the metallicity gradients (∇ Z ) of six Milky Way–like galaxies throughout their evolution.
Ayan Acharyya +9 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Two-process Model and Residual Abundance Analysis of the Milky Way Massive Satellites
The Astrophysical JournalThe “two-process model” is a promising technique for interpreting stellar chemical abundance data from large-scale surveys (e.g., the Sloan Digital Sky Survey IV/V and the Galactic Archeology with HERMES survey), enabling more quantitative empirical ...
Sten Hasselquist +6 more
doaj +1 more source
Ontogeny of color development in two green–brown polymorphic grasshopper species
Ecology and Evolution, 2023 Many insects, including several orthopterans, undergo dramatic changes in body coloration during ontogeny. This variation is particularly intriguing in gomphocerine grasshoppers, where the green and brown morphs appear to be genetically determined ...
Mahendra Varma +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Astrophysical JournalWe present an empirical chemical evolution model that explains the distribution of metals in the interstellar medium (ISM) and the circumgalactic medium (CGM) of galaxies based on the U niverse M achine and N eutral U niverse M achine models in the ...
Moka Nishigaki +7 more
doaj +1 more source
Chemical evolution in hierarchical scenarios
EPJ Web of Conferences, 2012 We studied the chemical properties of Milky-Way mass galaxies. We found common global chemical patterns with particularities which reflect their different assembly histories in a hierarchical scenario.
Tissera P.B.
doaj +1 more source
On the Galactic chemical evolution of sulfur [PDF]
Astronomy & Astrophysics, 2004 Accepted by A&A, 12 pages.
Ryde, N., Lambert, D. L.
openaire +2 more sources