Results 11 to 20 of about 1,764,141 (282)

Linking molecular evolution to molecular grafting [PDF]

Journal of Biological Chemistry, 2021
Molecular grafting is a strategy for the engineering of molecular scaffolds into new functional agents, such as next-generation therapeutics. Despite its wide use, studies so far have focused almost exclusively on demonstrating its utility rather than understanding the factors that lead to either poor or successful grafting outcomes.
Conan K. Wang, David J. Craik
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Cancer Molecular Evolution [PDF]

Journal of Molecular Evolution, 2015
By far, the majority of studies in molecular evolution have focused on genetic change across one or more generations. Much less is known about the genetic changes that occur during the life time of an individual, or somatic evolution, of which cancer is probably the best-known example.
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Galaxy chemical evolution models: The role of molecular gas formation [PDF]

, 2017
In our classical grid of multiphase chemical evolution models, star formation in the disc occurs in two steps: first, molecular gas forms, and then stars are created by cloud-cloud collisions or interactions of massive stars with the surrounding ...
Ascasibar, Yago, Díaz, Angeles I., Díaz, Ángeles I., Gibson, Brad K., Mollá, Mercedes   +4 more
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W(h)ither Fossils? Studying Morphological Character Evolution in the Age of Molecular Sequences [PDF]

, 2008
A major challenge in the post-genomics era will be to integrate molecular sequence data from extant organisms with morphological data from fossil and extant taxa into a single, coherent picture of phylogenetic relationships; only then will these ...
Bull J. J., Cuevas J., Desutter-Grandcolas L., Eernisse D. J., Elizabeth J. Hermsen, Giribet G., Grande L., Hedges S. B., Hermsen E. J., Horovitz I., Horovitz I., Jonathan R. Hendricks, Luckow M., Montgelard C., Norell M. A., Novacek M. J., O'Leary M., Rowe T., Simmons N. B., Wiens J. J., Xiang Q-Y. J., Zhang J.   +21 more
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Molecular Evolution of Aphthoviruses

Virus Genes, 1995
Aphthoviruses are an important group of animal pathogens. A combination of genetic and structural studies has revealed one of the main principles governing their evolution: severe limitations to variation imposed by functional and structural constraints, in conjunction with high mutation and recombination rates operating during genome replication ...
Domingo, Esteban, Mateu, Mauricio G., Escarmís, Cristina, Martínez-Salas, Encarnación, Andreu, David, Giralt, Ernest, Verdaguer, Núria, Fita, Ignacio   +7 more
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DNA Polymerases Engineered by Directed Evolution to Incorporate Nonstandard Nucleotides

Frontiers in Microbiology, 2014
DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ribonucleoside triphosphates. However, polymerases that can accept
Roberto eLaos, John Michael Thomson, Steven Albert Benner   +2 more
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THE MOLECULAR EVOLUTION OF ACTIN [PDF]

Genetics, 1986
ABSTRACT We have investigated the molecular evolution of plant and nonplant actin genes comparing nucleotide and amino acid sequences of 20 actin genes. Nucleotide changes resulting in amino acid substitutions (replacement substitutions) ranged from 3-7% for all pairwise comparisons of animal actin genes with the following exceptions ...
Richard B. Meagher, R.C. Hightower
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Elusive data underlying debate at the prokaryote-eukaryote divide

Biology Direct, 2018
Background The origin of eukaryotic cells was an important transition in evolution. The factors underlying the origin and evolutionary success of the eukaryote lineage are still discussed.
Marie Gerlitz, Michael Knopp, Nils Kapust, Joana C. Xavier, William F. Martin   +4 more
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A Hierarchical Approach to Protein Molecular Evolution [PDF]

, 1999
Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo ...
Crameri, Cwirla, Davidson, Devlin, Fisch, Gilbert, Gilbert, Gram, Griffiths, Hawkins, Kamtekar, Kauffman, Kauffman, Kepler, L. D. Bogarad, Lawrence, M. W. Deem, Maeshiro, Mandecki, Moore, Netzer, Patten, Pennisi, Perelson, Riddle, Scott, Shapiro, Shapiro, Stemmer, Stemmer, Zhang   +30 more
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Selective pressures on genomes in molecular evolution [PDF]

, 2003
We describe the evolution of macromolecules as an information transmission process and apply tools from Shannon information theory to it. This allows us to isolate three independent, competing selective pressures that we term compression, transmission ...
Adami, Adami, Adami, Ancel, Baake, Baake, Burch, Bürger, Cavalier-Smith, Charles Ofria, Christoph Adami, Clarke, Dawkins, Gatlin, Gerhart, Gibson, Kimura, Lenski, Mather, Mills, Modiano, Pavesi, Queitsch, Rutherford, Schneider, Schneider, Travis C. Collier, van Nimwegen, Waddington, Wagner, Wagner, Wilke, Wilke, Wilke, Wilke   +34 more
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