Results 41 to 50 of about 14,980 (199)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Spatial organization of the kelp microbiome at micron scales

Microbiome, 2022
Background Elucidating the spatial structure of host-associated microbial communities is essential for understanding taxon-taxon interactions within the microbiota and between microbiota and host. Macroalgae are colonized by complex microbial communities,
S. Tabita Ramírez-Puebla, Brooke L. Weigel, Loretha Jack, Cathleen Schlundt, Catherine A. Pfister, Jessica L. Mark Welch   +5 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Molecular evolution of human adenoviruses [PDF]

Scientific Reports, 2013
Scientific Reports | 3 ...
Rebecca A. Betensky, James Chodosh, Morris S. Jones, David W. Dyer, Mohammad A. Yousuf, Jeong Yoon Lee, Jaya Rajaiya, Gurdeep Singh, Christopher M. Robinson, Elizabeth B. Liu, Shoaleh Dehghan, Shoaleh Dehghan, Donald Seto   +12 more
openaire   +4 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Evolutionary genomics of socially polymorphic populations of Pogonomyrmex californicus

BMC Biology
Background Social insects vary considerably in their social organization both between and within species. In the California harvester ant, Pogonomyrmex californicus (Buckley 1867), colonies are commonly founded and headed by a single queen (haplometrosis,
Mohammed Errbii, Ulrich R. Ernst, Aparna Lajmi, Eyal Privman, Jürgen Gadau, Lukas Schrader   +5 more
doaj   +1 more source

Major Changes in Plastid Protein Import and the Origin of the Chloroplastida

iScience, 2020
Summary: Core components of plastid protein import and the principle of using N-terminal targeting sequences are conserved across the Archaeplastida, but lineage-specific differences exist.
Michael Knopp, Sriram G. Garg, Maria Handrich, Sven B. Gould   +3 more
doaj  

The molecular evolution of PL10 homologs [PDF]

BMC Evolutionary Biology, 2010
PL10 homologs exist in a wide range of eukaryotes from yeast, plants to animals. They share a DEAD motif and belong to the DEAD-box polypeptide 3 (DDX3) subfamily with a major role in RNA metabolism. The lineage-specific expression patterns and various genomic structures and locations of PL10 homologs indicate these homologs have an interesting ...
Ti Cheng Chang, Wan Sheng Liu
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Incompatibility and interchangeability in molecular evolution

Genome Biology and Evolution, 2022
There is remarkable variation in the rate at which genetic incompatibilities in molecular interactions accumulate. In some cases, minor changes – even single nucleotide substitutions – create major epistatic incompatibilities when hybridization forces new variants to function in a novel genetic background from an isolated population.
Daniel B Sloan, Jessica M Warren, Alissa M Williams, Shady A Kuster, Evan S Forsythe   +4 more
openaire   +2 more sources