Results 71 to 80 of about 1,854,423 (305)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Molecular Clock on a Neutral Network [PDF]
, 2007 The number of fixed mutations accumulated in an evolving population often displays a variance that is significantly larger than the mean (the overdispersed molecular clock). By examining a generic evolutionary process on a neutral network of high-fitness genotypes, we establish a formalism for computing all cumulants of the full probability ...
arxiv +1 more source
Molecular Dynamics approach of sol–gel transition: Comparison with experiments [PDF]
, 2005 A new aggregation model by a Molecular Dynamics approach at constant temperature was compared with experimental results on a zirconia precursor gelling process.
Dauger, Alain +3 more
core +3 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Evolutionary genomics of socially polymorphic populations of Pogonomyrmex californicus
BMC BiologyBackground Social insects vary considerably in their social organization both between and within species. In the California harvester ant, Pogonomyrmex californicus (Buckley 1867), colonies are commonly founded and headed by a single queen (haplometrosis,
Mohammed Errbii +5 more
doaj +1 more source
Selection for size in molecular self-assembly drives the de novo evolution of a molecular machine [PDF]
arXiv, 2022 The functioning of machines typically requires a concerted action of their parts. This requirement also holds for molecular motors that drive vital cellular processes and imposes constraints on their conformational changes as well as the rates at which they occur. It remains unclear whether features required for functional molecular machines can emerge
arxiv
Automated mining of the ALMA archive in the COSMOS field (A3COSMOS): II. Cold molecular gas evolution out to Redshift 6 [PDF]
, 2019 We present new measurements of the cosmic cold molecular gas evolution out to redshift 6 based on systematic mining of the ALMA public archive in the COSMOS deep field (A3COSMOS).
Bertoldi, F +15 more
core +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Scientific Reports, 2021 Global climate change represents a critical threat to the environment since it influences organismic interactions, such as the host-parasite systems, mainly in ectotherms including fishes.
Jaqueline Custodio da Costa +4 more
doaj +1 more source
Protein-rich diet decreases survival, but does not alter reproduction, in fertile ant workers
Frontiers in Ecology and Evolution, 2023 Aging is associated with diverse molecular processes such as oxidative damage, decrease in immunocompetence, or increase in epigenetic abnormalities, mutations, and inflammations. Many of these processes are linked to nutrient-sensing signalling pathways,
Marina Choppin +3 more
doaj +1 more source