Results 81 to 90 of about 218,478 (262)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Balitsky-JIMWLK evolution equation at NLO

EPJ Web of Conferences, 2014
Wilson line operators are infinite gauge factors ordered along the straight lines of the fast moving particles. Scattering amplitudes of proton-Nucleus or Nucleus-Nucleus collisions at high-energy are written in terms of matrix elements of these ...
Chirilli Giovanni Antonio
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A stochastic version of the Price equation reveals the interplay of deterministic and stochastic processes in evolution

BMC Evolutionary Biology, 2008
Background Evolution involves both deterministic and random processes, both of which are known to contribute to directional evolutionary change.
Rice Sean H
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Review of Some Modified Generalized Korteweg–de Vries–Kuramoto–Sivashinsky Equations (Part II)

Foundations
In part I of this work to appear in Foudations-MDPI 2024, some existence and uniqueness results for the solutions of some equations were reviewed, such as the Korteweg–de Vries equation (KdV), the Kuramoto–Sivashinsky equation (KS), the generalized ...
Marie-Thérèse Aimar, Abdelkader Intissar   +1 more
doaj   +1 more source

Evolution Equations as Space-Time Operator Equations

Journal of Mathematical Analysis and Applications, 1993
The author presents the transition from the classical semigroup theory for the initial value problem \[ \dot u(t)= 2\pi i Au(t)+ f(t), \quad t>0, \qquad u(0)= u_ 0\in Y_ 1\equiv D_ 0 (A) \] with \(f\in C_ 1 (\overline {\mathbb{R}}_ +, y)\) to the so-called ``space-time evolution problem'' \[ ((D_ \nu -A)- i\nu) u= (2\pi i)^{-1} (f+ \text{sgn} (\nu ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Delay Rough Evolution Equations

Potential Analysis
In this paper, we accomplish the existence and stability of the solution of a class of delay rough partial differential equations (DRPDEs). Moreover, we prove that the solution of DRPDEs can converge to that of RPDEs in sense of some distance as the delay tends to zero.
Qu, Shiduo, Gao, Hongjun
openaire   +2 more sources