Results 51 to 60 of about 27,787 (252)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Inferring to cooperate: Evolutionary games with Bayesian inferential strategies

New Journal of Physics
Strategies for sustaining cooperation and preventing exploitation by selfish agents in repeated games have mostly been restricted to Markovian strategies where the response of an agent depends on the actions in the previous round.
Arunava Patra, Supratim Sengupta, Ayan Paul, Sagar Chakraborty   +3 more
doaj   +1 more source

Study on the Dynamic Evolution of Transverse Collusive Bidding Behavior and Regulation Countermeasures Under the “Machine-Managed Bidding” System

Buildings
The Machine-Managed Bidding (MMB) system is an innovative bidding mode implemented by the Chinese government to mitigate collusive bidding behavior. Prior studies have focused minimally on the bidding mechanism and the possible collusive bidding behavior
Zongyuan Zhang, Jincan Liu, Zhitian Zhang, Bin Chen   +3 more
doaj   +1 more source

The Hitchhiker’s Guide to Adaptive Dynamics

Games, 2013
Adaptive dynamics is a mathematical framework for studying evolution. It extends evolutionary game theory to account for more realistic ecological dynamics and it can incorporate both frequency- and density-dependent selection.
Jacob Johansson, Niels von Festenberg, Åke Brännström   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Evolutionarily stable payoff matrix in hawk–dove games

BMC Ecology and Evolution
Background Classical matrix game models aim to find the endpoint of behavioural evolution for a set of fixed possible interaction outcomes. Here, we introduce an evolutionary model in which not only the players’ strategies but also the payoff matrix ...
Balázs Király, Tamás Varga, György Szabó, József Garay   +3 more
doaj   +1 more source

Using Game Theory to Model the Evolution of Information: an Illustrative Game

Entropy, 2002
: The application of information theory to biology can be broadly split into three areas: (i) At the level of the genome; considering the storage of information using the genetic code.
Mark Broom
doaj   +1 more source

Beating your Neighbor to the Berry Patch

Peer Community Journal, 2022
Foragers often compete for resources that ripen (or otherwise improve) gradually. What strategy is optimal in this situation? It turns out that there is no optimal strategy. There is no evolutionarily stable strategy (ESS), and the only Nash equilibrium (
Rogers, Alan R.
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source