Results 61 to 70 of about 389,475 (313)

Treatment planning with a 2.5 MV photon beam for radiation therapy

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose The shallow depth of maximum dose and higher dose fall‐off gradient of a 2.5 MV beam along the central axis that is available for imaging on linear accelerators is investigated for treatment of shallow tumors and sparing the organs at risk (OARs) beyond it.
Navid Khaledi, Chris Hayes, Louise Belshaw, Mark Grattan, Rao Khan, James L. Gräfe   +5 more
wiley   +1 more source

Environmental influence on Pristionchus pacificus mouth form through different culture methods

Scientific Reports, 2017
Environmental cues can impact development to elicit distinct phenotypes in the adult. The consequences of phenotypic plasticity can have profound effects on morphology, life cycle, and behavior to increase the fitness of the organism.
Michael S. Werner, Bogdan Sieriebriennikov, Tobias Loschko, Suryesh Namdeo, Masa Lenuzzi, Mohannad Dardiry, Tess Renahan, Devansh Raj Sharma, Ralf J. Sommer   +8 more
doaj   +1 more source

The use of information theory in evolutionary biology [PDF]

Annals NY Acad. Sciences 1256 (2012) 49-65, 2011
Information is a key concept in evolutionary biology. Information is stored in biological organism's genomes, and used to generate the organism as well as to maintain and control it. Information is also "that which evolves". When a population adapts to a local environment, information about this environment is fixed in a representative genome. However,
arxiv   +1 more source

Evolutionary Biology for the 21st Century

PLoS Biology, 2013
New theoretical and conceptual frameworks are required for evolutionary biology to capitalize on the wealth of data now becoming available from the study of genomes, phenotypes, and organisms - including humans - in their natural environments.
H. Allen Orr, Jonathan B. Losos, Stevan J. Arnold, Susanne S. Renner, Robert E. Ricklefs, Dmitri A. Petrov, Thomas L. Turner, Antónia Monteiro, Hopi E. Hoekstra, David S. Hibbett, Gill Bejerano, Pamela S. Soltis, Craig Moritz, Craig Moritz, David P. Mindell, Edmund D. Brodie   +15 more
openaire   +6 more sources

Evolutionary Biology: Speciation on Islands [PDF]

Current Biology, 2010
One of the strongest rules of biological diversity - the observation that more species live on large islands than on small ones - is usually attributed to the balance between colonization and extinction. But speciation on islands cannot be ignored.
Richard E. Glor, Daven C. Presgraves
openaire   +3 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud   +13 more
wiley   +1 more source

Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene eud-1 control predatory feeding plasticity

Nature Communications, 2016
In the nematode Pristionchus pacificus, a developmental switch, the sulfatase eud-1, controls mouth-form plasticity. Here, the authors show that mutations in two conserved histone modifying enzymes mimic the eud-1 phenotype, in part mediated by an ...
Vahan Serobyan, Hua Xiao, Suryesh Namdeo, Christian Rödelsperger, Bogdan Sieriebriennikov, Hanh Witte, Waltraud Röseler, Ralf J. Sommer   +7 more
doaj   +1 more source

Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance [PDF]

, 2014
A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor reoccurs. Genome sequencing and computational analysis allows to computational dissection of clones from tumors, while singe-cell genome sequencing ...
arxiv   +1 more source

Evolution of macromolecular structure: a 'double tale' of biological accretion [PDF]

Science Progress 101(4):360-383, 2018, 2018
The evolution of structure in biology is driven by accretion and change. Accretion brings together disparate parts to form bigger wholes. Change provides opportunities for growth and innovation. Here we review patterns and processes that are responsible for a 'double tale' of evolutionary accretion at various levels of complexity, from proteins and ...
arxiv   +1 more source