Results 71 to 80 of about 3,031,483 (337)

IEEE Transactions on Evolutionary Computation

open access: yes, 2019
Digital Object Identifier 10.1109/TEVC.2020.3035222 IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION is published by the IEEE Computational Intelligence Society (formerly Neural Networks Society) on behalf of the following 13 societies: Circuits and Systems;
LI Yun   +3 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

A Technique for Improving Web Mining using Enhanced Genetic Algorithm [PDF]

open access: yesJournal of Artificial Intelligence and Data Mining, 2019
World Wide Web is growing at a very fast pace and makes a lot of information available to the public. Search engines used conventional methods to retrieve information on the Web; however, the search results of these engines are still able to be refined ...
F. Nosratian, H. Nematzadeh, H. Motameni
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

Evolutionary multiobjective optimization: open research areas and some challenges lying ahead

open access: yesComplex & Intelligent Systems, 2019
Evolutionary multiobjective optimization has been a research area since the mid-1980s, and has experienced a very significant activity in the last 20 years. However, and in spite of the maturity of this field, there are still several important challenges
Carlos A. Coello Coello   +4 more
doaj   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Knowledge Learning for Evolutionary Computation

open access: yesIEEE Transactions on Evolutionary Computation
Evolutionary computation (EC) is a kind of meta-heuristic algorithm that takes inspiration from natural evolution and swarm intelligence behaviors. In the EC algorithm, there is a huge amount of data generated during the evolutionary process.
Yiyi Jiang   +3 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

基于进化计算的多任务可调机构刚体导引综合

open access: yesJixie chuandong, 2005
The method of rigid-body guidance synthesis of adjustable mechanisms for multiple alternation tasks based on evolutionary computation is proposed.The mechanism optimization model of multi-tasks is established,and the global optimization solution will be ...
杨志刚   +3 more
doaj  

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