Results 111 to 120 of about 818,001 (295)
Correction to: A common gene drive language eases regulatory process and eco-evolutionary extensions
BMC Ecology and Evolution, 2021 Prateek Verma +2 more
doaj +1 more source
Survival of dominated strategies under evolutionary dynamics [PDF]
We prove that any deterministic evolutionary dynamic satisfying four mild requirements fails to eliminate strictly dominated strategies in some games.
Hofbauer, Josef, Sandholm, William H.
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Population genomics of intrapatient HIV-1 evolution
eLife, 2015 Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolved and genome wide data including rare variants are essential.
Fabio Zanini +6 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Evolutionary ApplicationsThe symposium “Evolutionary Applications” took place on June 28, 2024 in the virtual part of the 3rd Joint Congress on Evolutionary Biology. It was contributed to the conference by the European Society for Evolutionary Biology (ESEB).
Hildegard Uecker
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity
Nature Communications, 2017 How a trait evolves depends on the shape of its fitness trade-off. Here, Huang et al. demonstrate evolution of trade-off shape in an experimental predator-prey system and develop a mathematical model of trait evolution when the underlying trade-off can ...
Weini Huang +4 more
doaj +1 more source
Environmental innovation and industrial dynamics: the contributions of evolutionary economics [PDF]
The purpose of this article is to discuss the contributions of the evolutionary theory of innovation on the micro and meso dynamics of environmental innovations.
Vanessa OLTRA (GREThA UMR CNRS 5113)
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source