Results 91 to 100 of about 818,001 (295)

Amplification on Undirected Population Structures: Comets Beat Stars

Scientific Reports, 2017
The fixation probability is the probability that a new mutant introduced in a homogeneous population eventually takes over the entire population.
Andreas Pavlogiannis, Josef Tkadlec, Krishnendu Chatterjee, Martin A. Nowak   +3 more
doaj   +1 more source

Evolutionary Quantum Dynamics of a Generic Universe

, 2006
The implications of an Evolutionary Quantum Gravity are addressed in view of formulating a new dark matter candidate. We consider a Schr\"odinger dynamics for the gravitational field associated to a generic cosmological model and then we solve the ...
Belinski, Benini, Berger, Brown, Corvino, DeWitt, Donato, Einasto, Giovanni Montani, Imponente, Isham, Kirillov, Kirillov, Kirillov, Kirillov, Kirillov, Kolb, Kuchar, Kuchar, MacGibbon, Marco Valerio Battisti, Mercuri, Mercuri, Misner, Misner, Montani, Montani, Montani, Montani, Ostriker, Polchinski, Polchinski, Roberts, Rovelli, Rovelli, Rovelli, Rubin, Shestakova, Shestakova   +38 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Individual dietary specialization in a generalist predator: A stable isotope analysis of urban and rural red foxes

Ecology and Evolution, 2020
Some carnivores are known to survive well in urban habitats, yet the underlying behavioral tactics are poorly understood. One likely explanation for the success in urban habitats might be that carnivores are generalist consumers.
Carolin Scholz, Jasmin Firozpoor, Stephanie Kramer‐Schadt, Pierre Gras, Christoph Schulze, Sophia E. Kimmig, Christian C. Voigt, Sylvia Ortmann   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Slow manifolds for a nonlocal fast-slow stochastic evolutionary system with stable Levy noise

, 2019
This work aims at understanding the slow dynamics of a nonlocal fast-slow stochastic evolutionary system with stable Levy noise. Slow manifolds along with exponential tracking property for a nonlocal fast-slow stochastic evolutionary system with stable ...
Duan, Jinqiao, He, Ziying, Yuan, Shenglan, Zulfiqar, Hina   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The many dimensions of combination therapy: How to combine antibiotics to limit resistance evolution

Evolutionary Applications
In combination therapy, bacteria are challenged with two or more antibiotics simultaneously. Ideally, separate mutations are required to adapt to each of them, which is a priori expected to hinder the evolution of full resistance.
Christin Nyhoegen, Sebastian Bonhoeffer, Hildegard Uecker   +2 more
doaj   +1 more source

Crosstalk in concurrent repeated games impedes direct reciprocity and requires stronger levels of forgiveness

Nature Communications, 2018
Social interactions among people are often repeated, and yet it is assumed that simultaneous interactions are independent from one another. Here, Reiter and colleagues describe a conceptual framework where an action in one game can influence the decision
Johannes G. Reiter, Christian Hilbe, David G. Rand, Krishnendu Chatterjee, Martin A. Nowak   +4 more
doaj   +1 more source

Evolution of Human-like Social Grooming Strategies regarding Richness and Group Size

, 2018
Human beings tend to cooperate with close friends, therefore they have to construct strong social relationships to recieve cooperation from others.
Ichinose, Genki, Takano, Masanori
core   +2 more sources