Results 71 to 80 of about 818,001 (295)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Food quality influences behavioural flexibility and cognition in wild house mice
Scientific ReportsEnvironmental change is frequent. To adjust and survive, animals need behavioural flexibility. Recently, cognitive flexibility has emerged as a driving force for adjusting to environmental change.
Ekaterina Gorshkova +3 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
InsectsThe fall armyworm, Spodoptera frugiperda, is a long-distance migratory pest, which invaded the African continent in 2016, causing enormous losses to agricultural crops, especially maize.
Mobolade D. Akinbuluma +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Population size changes and selection drive patterns of parallel evolution in a host–virus system
Nature Communications, 2018 Pathogens exert strong selection on hosts and thus may promote parallel evolution. Here, the authors find that hosts experimentally coevolving with a virus have parallel changes in population size, phenotype, and genomic regions, but accelerated ...
Jens Frickel +3 more
doaj +1 more source
Collective narratives catalyse cooperation
Humanities & Social Sciences Communications, 2022 Humans invest in fantastic stories—mythologies. Recent evolutionary theories suggest that cultural selection may favour moralising stories that motivate prosocial behaviours.
Chaitanya S. Gokhale +2 more
doaj +1 more source
Evolutionary dynamics in structured populations [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 Abstract Evolutionary dynamics shape the living world around us. At the centre of every evolutionary process is a population of reproducing individuals. The structure of that population affects evolutionary dynamics. The individuals can be molecules, cells, viruses, multicellular organisms or humans.
Nowak, Martin +2 more
openaire +3 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source