Results 71 to 80 of about 3,953,318 (310)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Evolutionary shift dynamics on a cycle [PDF]
Journal of Theoretical Biology, 2012 We present a new model of evolutionary dynamics in one-dimensional space. Individuals are arranged on a cycle. When a new offspring is born, another individual dies and the rest shift around the cycle to make room. This rule, which is inspired by spatial evolution in somatic tissue and microbial colonies, has the remarkable property that, in the limit ...
Allen, Benjamin, Nowak, Martin A.
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Evolutionary stability of first price auctions [PDF]
, 2010 Louge F, Riedel F. Evolutionary stability of first price auctions. Working Papers. Institute of Mathematical Economics. Vol 435. Bielefeld: Universität Bielefeld; 2010.This paper studies the evolutionary stability of the unique Nash equilibrium of a ...
Louge, Fernando +2 more
core
Spatial dilemmas of diffusible public goods
eLife, 2013 The emergence of cooperation is a central question in evolutionary biology. Microorganisms often cooperate by producing a chemical resource (a public good) that benefits other cells.
Benjamin Allen +2 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Local disalignment can promote coherent collective motion
New Journal of Physics, 2013 When particles move at a constant speed and have the tendency to align their directions of motion, ordered large-scale movement can emerge despite significant levels of noise.
M Meschede, O Hallatschek
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Animal models with group-specific additive genetic variances: extending genetic group models
Genetics Selection Evolution, 2019 Background The animal model is a key tool in quantitative genetics and has been used extensively to estimate fundamental parameters, such as additive genetic variance or heritability.
Stefanie Muff +4 more
doaj +1 more source