Results 51 to 60 of about 234,739 (311)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The role of genetic diversity in the evolution and maintenance of environmentally-cued, male alternative reproductive tactics

BMC Evolutionary Biology, 2019
Background Alternative reproductive tactics (ARTs) are taxonomically pervasive strategies adopted by individuals to maximize reproductive success within populations.
K. A. Stewart, R. Draaijer, M. R. Kolasa, I. M. Smallegange   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The diversity of eco-evolutionary dynamics: comparing the feedbacks between ecology and evolution across scales [PDF]

, 2019
1.Evidence of reciprocal influences between ecological and evolutionary processes (eco‐evolutionary dynamics) is accumulating at different levels of biological organisation, ranging from populations to communities and even ecosystems.
Eizaguirre, C., Deere, Jacques A., Raeymaekers, J.A.M., Eizaguirre, C, Brunner, FS, Deere, JA, Egas, M., Martijn Egas, Raeymaekers, Joost A.M., Deere, J.A., Eizaguirre, Christophe, Jacques A. Deere, Egas, Martijn, Franziska S. Brunner, Egas, M, Raeymaekers, JAM, Brunner, F.S., Joost A. M. Raeymaekers, Christophe Eizaguirre, Brunner, Franziska S.   +19 more
core   +1 more source

A dynamical limit to evolutionary adaptation

Proceedings of the National Academy of Sciences, 2023
Natural selection makes evolutionary adaptation possible even if the overwhelming majority of new mutations are deleterious. However, in rapidly evolving populations where numerous linked mutations occur and segregate simultaneously, clonal interference and genetic hitchhiking can limit the efficiency of selection, allowing deleterious mutations to ...
Matthew J. Melissa, Michael M. Desai
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Food quality influences behavioural flexibility and cognition in wild house mice

Scientific Reports
Environmental change is frequent. To adjust and survive, animals need behavioural flexibility. Recently, cognitive flexibility has emerged as a driving force for adjusting to environmental change.
Ekaterina Gorshkova, Stella Kyomen, Markéta Kaucká, Anja Guenther   +3 more
doaj   +1 more source

A dynamic multiobjective evolutionary algorithm based on a dynamic evolutionary environment model [PDF]

Swarm and Evolutionary Computation, 2019
Abstract Traditional dynamic multiobjective evolutionary algorithms usually imitate the evolution of nature, maintaining diversity of population through different strategies and making the population track the Pareto optimal solution set efficiently after the environmental change.
Juan Zou, Qingya Li, Shengxiang Yang, Jinhua Zheng, Zhou Peng, Tingrui Pei   +5 more
openaire   +2 more sources

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source