Results 41 to 50 of about 234,739 (311)
What makes a successful species? Traits facilitating survival in altered tropical forests
BMC Ecology, 2017 Background Ongoing conversion, disturbance and fragmentation of tropical forests stress this ecosystem and cause the decline or disappearance of many species.
Mareike Hirschfeld, Mark-Oliver Rödel
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Reconstructing metastatic seeding patterns of human cancers
Nature Communications, 2017 Tumours frequently metastasize to multiple anatomical sites and understanding how these different metastases evolve may be important for therapy. Here, the authors develop a method—Treeomics—that can construct phylogenies from multiple metastases from ...
Johannes G. Reiter +7 more
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Structurally rich dry grasslands – Potential stepping stones for bats in open farmland
Frontiers in Ecology and Evolution, 2023 Agricultural intensification has caused decrease and fragmentation of European semi-natural dry grasslands. While a high biodiversity value of dry grasslands is acknowledged for plants and insects, locally and on landscape level, their relevance for ...
Sophie P. Ewert +6 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Synthetic Symbiosis under Environmental Disturbances
mSystems, 2020 By virtue of complex ecologies, the behavior of mutualisms is challenging to study and nearly impossible to predict. However, laboratory engineered mutualistic systems facilitate a better understanding of their bare essentials.
Jai A. Denton, Chaitanya S. Gokhale
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Extortion strategies resist disciplining when higher competitiveness is rewarded with extra gain
Nature Communications, 2019 In game theory, ‘extortionate’ tactics in two-player games are predicted to give way to ‘generous’ strategies. Here, the authors show in a human experimental sample that extortion can prevail as a strategy in games in which there is a specific reward for
Lutz Becks, Manfred Milinski
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
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Evolutionary Dynamics of Extremal Optimization [PDF]
Journal of Computational Interdisciplinary Sciences, 2009 Dynamic features of the recently introduced extremal optimization heuristic are analyzed. Numerical studies of this evolutionary search heuristic show that it performs optimally at a transition between a jammed and an diffusive state. Using a simple, annealed model, some of the key features of extremal optimization are explained.
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