Results 41 to 50 of about 189,605 (265)

Reconstructing metastatic seeding patterns of human cancers

Nature Communications, 2017
Tumours frequently metastasize to multiple anatomical sites and understanding how these different metastases evolve may be important for therapy. Here, the authors develop a method—Treeomics—that can construct phylogenies from multiple metastases from ...
Johannes G. Reiter, Alvin P. Makohon-Moore, Jeffrey M. Gerold, Ivana Bozic, Krishnendu Chatterjee, Christine A. Iacobuzio-Donahue, Bert Vogelstein, Martin A. Nowak   +7 more
doaj   +1 more source

Structurally rich dry grasslands – Potential stepping stones for bats in open farmland

Frontiers in Ecology and Evolution, 2023
Agricultural intensification has caused decrease and fragmentation of European semi-natural dry grasslands. While a high biodiversity value of dry grasslands is acknowledged for plants and insects, locally and on landscape level, their relevance for ...
Sophie P. Ewert, Sophie P. Ewert, Mirjam Knörnschild, Mirjam Knörnschild, Mirjam Knörnschild, Kirsten Jung, Karl-Heinz Frommolt   +6 more
doaj   +1 more source

Evolutionary Dynamics of Extremal Optimization [PDF]

Journal of Computational Interdisciplinary Sciences, 2009
Dynamic features of the recently introduced extremal optimization heuristic are analyzed. Numerical studies of this evolutionary search heuristic show that it performs optimally at a transition between a jammed and an diffusive state. Using a simple, annealed model, some of the key features of extremal optimization are explained.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Synthetic Symbiosis under Environmental Disturbances

mSystems, 2020
By virtue of complex ecologies, the behavior of mutualisms is challenging to study and nearly impossible to predict. However, laboratory engineered mutualistic systems facilitate a better understanding of their bare essentials.
Jai A. Denton, Chaitanya S. Gokhale
doaj   +3 more sources

Extortion strategies resist disciplining when higher competitiveness is rewarded with extra gain

Nature Communications, 2019
In game theory, ‘extortionate’ tactics in two-player games are predicted to give way to ‘generous’ strategies. Here, the authors show in a human experimental sample that extortion can prevail as a strategy in games in which there is a specific reward for
Lutz Becks, Manfred Milinski
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source