Results 41 to 50 of about 4,260,217 (298)

Thinking About Evolutionary Mechanisms: Natural Selection [PDF]

open access: yes, 2004
This paper explores whether natural selection, a putative evolutionary mechanism, and a main one at that, can be characterized on either of the two dominant conceptions of mechanism, due to Glennan and the team of Machamer, Darden, and Craver, that ...
Skipper, Robert, Millstein, Roberta
core  

Evolutionary ecology of hares (Lepus spp.) from northwest Africa: the existence of cryptic species and description of a new species (Lepus saharae sp. nov.) [PDF]

open access: yes, 2019
Objective: We examine the different pressures that lead to the occurrence of new species and thus to their phylogenies. From an evolutionary ecology perspective, we examine the phylogenetic relationships of different lineages, as well as the evolutionary
Donat-Torres, Maria Pilar   +3 more
core   +1 more source

Investigating sex differences in developmental origins of adolescent depression

open access: yesFrontiers in Child and Adolescent Psychiatry
IntroductionEvolutionary hypotheses propose that fetuses show “predictive adaptive” responses to the prenatal environment based on likely continuity with the postnatal environment, and males and females have different adaptive priorities.
Elizabeth C. Braithwaite   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ensemble-Based Binding Free Energy Profiling and Network Analysis of the KRAS Interactions with DARPin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants and Universal Architecture of Regulatory Hotspots and Allosteric Binding

open access: yesBiomolecules
KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allostery ...
Mohammed Alshahrani   +3 more
doaj   +1 more source

Evolutionary synthesis of kinematic mechanisms [PDF]

open access: yesArtificial Intelligence for Engineering Design, Analysis and Manufacturing, 2008
AbstractThis paper discusses the application of genetic programming to the synthesis of compound two-dimensional kinematic mechanisms, and benchmarks the results against one of the classical kinematic challenges of 19th century mechanical design. Considerations for selecting a representation for mechanism design are presented, and a number of human ...
openaire   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The Trade-Off Between Sanitizer Resistance and Virulence Genes: Genomic Insights into E. coli Adaptation

open access: yesAntibiotics
Background: Escherichia coli is one of the most studied bacteria worldwide due to its genetic plasticity. Recently, in addition to characterizing its pathogenic potential, research has focused on understanding its resistance profile to inhibitory agents,
Vinicius Silva Castro   +5 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

How did multicellularity originate? Mechanisms explaining a decisive evolutionary innovation

open access: yes, 2021
2 Pags. This is a translation of an article I wrote in Spanish, published in The Conversation-E on June 15, 2021: https://theconversation.com/la-multicelularidad-fue-una-de-las-mayores-innovaciones-de-la-evolucion-como-se-origino-161629.The ...
Yruela Guerrero, Inmaculada
core  

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