Results 41 to 50 of about 262,011 (266)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The complete mitochondrial genome of Poropanchax normani and phylogenetic studies of Cyprinodontidaes

open access: yesMitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genome of the Cyprinodontiformes fish Poropanchax normani was studied in this study. The size of the entire mitochondrial genome was 16,878 bp, and the total length of the encoding sequence was 11,435 bp, accounting for 67.75%,
Chuanchen Ren   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The Genus Petunia (Solanaceae): Evolutionary Synthesis and Taxonomic Review

open access: yesPlants
Many plant groups exhibit complex evolutionary processes, including hybridization, incomplete lineage sorting, and variable evolutionary rates, which make species delimitation challenging.
Luana S. Soares   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Complete Mitochondrial Genomes and Phylogenetic Relationships of Myotis siligorensis and Myotis laniger

open access: yesEcology and Evolution
Bats belong to the order Chiroptera, which represents the second most diverse order among mammals. Bats provide critical ecosystem services through mosquito population control, suppression of agricultural arthropod pests, pollination facilitation, and ...
Xiao‐Die Chen   +4 more
doaj   +1 more source

Complete mitochondrial genome of Procapra picticaudata, with phylogenetic implication

open access: yesMitochondrial DNA. Part B. Resources, 2019
The Tibetan gazelle Procapra picticaudata is endemic to the Tibetan plateau. The species is listed as a Near Threatened (NT) species by the IUCN Red List of Threatened Animals and the Red List of China’s Vertebrates.
Ke-Ji Guo   +8 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

The complete mitochondrial genome of Geochelone sulcata

open access: yesMitochondrial DNA. Part B. Resources, 2017
The complete mitochondrial genome of Geochelone sulcata was determined using PCR, Long-PCR with length of 16,692 bp. The genome organization, gene order, and base composition was similar to typical vertebrate.
Qiong Shi   +4 more
doaj   +1 more source

On the evolutionary relationship between chondrocytes and osteoblasts [PDF]

open access: yesFrontiers in Genetics, 2015
Vertebrates are the only animals that produce bone, but the molecular genetic basis for this evolutionary novelty remains obscure. Here, we synthesize information from traditional evolutionary and modern molecular genetic studies in order to generate a working hypothesis on the evolution of the gene regulatory network (GRN) underlying bone formation ...
Gómez-Picos, Patsy, Eames, B. Frank
openaire   +3 more sources

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