Results 31 to 40 of about 123,245 (256)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Changing-Look AGNs or Short-Lived Radio Sources?

Frontiers in Astronomy and Space Sciences, 2017
The evolution of extragalactic radio sources has been a fundamental problem in the study of active galactic nuclei for many years. A standard evolutionary model has been created based on observations of a wide range of radio sources.
Aleksandra Wołowska, Magdalena Kunert-Bajraszewska, Kunal Mooley, Gregg Hallinan   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A conservation planning strategy applied to the evolutionary history of the mantellid frogs of Madagascar

npj Biodiversity, 2023
Phylogenetic diversity is an increasingly applied metric used to maximize the representation of evolutionary history in spatial conservation planning. When following this approach, researchers commonly overlook sites with a relatively higher proportion ...
Miguel R. Ferreira, Francesco Belluardo, Walter Cocca, Angelica Crottini, Sílvia B. Carvalho   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multi-Objective Quantum Inspired Evolutionary SLM Scheme for PAPR Reduction in Multi-Carrier Modulation

IEEE Access, 2020
As an efficient wireless transmission technology, multi-carrier communication find its way in many applications. However, high peak to average power ratio (PAPR) of the signal degrades the system performance.
Jun Hou, Wei Wang, Yang Zhang, Xinyi Liu, Ying Xie   +4 more
doaj   +1 more source

Assessment of Optimization Methods for Aeroacoustic Prediction of Trailing-Edge Interaction Noise in Axisymmetric Jets

Mathematics, 2021
Our concern in this paper is in the fine-tuning of the arbitrary parameters within the upstream turbulence structure for the acoustic spectrum of a rapid-distortion theory (RDT)-based model of trailing-edge noise.
Sarah Stirrat, Mohammed Z. Afsar, Edmondo Minisci   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

INSTANTANEOUS FREQUENCY ESTIMATION USING A LEAST SQUARES TIME-FREQUENCY METHOD

Electrica, 2004
We present a method for estimating the instantaneous frequency of a signal. This method involves the calculation of a time-frequency energy density of the signal, then obtaining an instantaneous frequency estimation from this joint density.
Mahmut ÖZTÜRK, Aydın AKAN
doaj   +2 more sources