Results 61 to 70 of about 3,164,796 (323)

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

A non-separable stochastic model for pulse-like ground motions [PDF]

open access: yes, 2013
A phenomenological non-separable non-stationary stochastic model is proposed to represent near-fault pulse-like ground motions (PLGMs) by means of a parametrically defined evolutionary power spectrum (EPSD). Numerical data pertaining to ensembles of EPSD
Giaralis, A., Lungu, A.
core  

A LOFAR view on the duty cycle of young radio sources [PDF]

open access: yes, 2015
Compact Steep Spectrum, Gigahertz Peaked Spectrum and High Frequency Peak (CSS, GPS, HFP) sources are considered to be young radio sources but the details of their duty cycle are not well understood.
An   +29 more
core   +3 more sources

Comorbid Analysis of Genes Associated with Autism Spectrum Disorders Reveals Differential Evolutionary Constraints. [PDF]

open access: yesPLoS ONE, 2016
The burden of comorbidity in Autism Spectrum Disorder (ASD) is substantial. The symptoms of autism overlap with many other human conditions, reflecting common molecular pathologies suggesting that cross-disorder analysis will help prioritize autism gene ...
Maude M David   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Spectroscopic evolution of dusty starburst galaxies [PDF]

open access: yes, 2001
By using a one-zone chemical and spectrophotometric evolution model of a disk galaxy undergoing a dusty starburst, we investigate, numerically, the optical spectroscopic properties in order to explore galaxy evolution in distant clusters.
Arimoto N.   +14 more
core   +2 more sources

HD152786: A LITHIUM GIANT?

open access: yesOdessa Astronomical Publications, 2007
We were presented poster about interpretation of spectrum of the late-type lithium star HD152786 acquired within UVES Paranal Observatory Project. Using the Synspec code for synthetic spectrum calculations we obtained some physical characteristics of the
T. Kratka, V. Stefl
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster

open access: yes, 2004
Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features such as the prevalence of specific subgraphs or duplicate ...
B. Bollobás   +11 more
core   +1 more source

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