Results 71 to 80 of about 3,164,796 (323)
A Rate Distortion approach to protein symmetry [PDF]
, 2010 A spontaneous symmetry breaking argument is applied to the problem of protein form, via a Rate Distortion analysis of the relation between genome coding and the final condensation of the protein 'molten globule'.
Rodrick Wallace
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Spectral signatures of photosynthesis I: Review of Earth organisms
, 2007 Why do plants reflect in the green and have a 'red edge' in the red, and should extrasolar photosynthesis be the same? We provide: 1) a brief review of how photosynthesis works; 2) an overview of the diversity of photosynthetic organisms, their light ...
Bebout B.M. +13 more
core +1 more source
Electrica, 2006 We present a method for estimating the instantaneous frequency of the multi-component signals. This method involves the calculation of a time-frequency energy density of the signal, then obtaining an instantaneous frequency estimation from this joint ...
Mahmut ÖZTÜRK, Aydın AKAN
doaj +2 more sources
SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2.
PLoS ONE, 2020 SARS-CoV-2 is still rampaging throughout the world while the many evolutionary studies on it are simultaneously springing up. Researchers have simply utilized the public RNA-seq data to find out the so-called SNPs in the virus genome.
Yue Li +6 more
doaj +1 more source
Positive Discrete Spectrum of the Evolutionary Operator of Supercritical Branching Walks with Heavy Tails [PDF]
, 2015 We consider a continuous-time symmetric supercritical branching random walk on a multidimensional lattice with a finite set of the particle generation centres, i.e. branching sources.
E. Yarovaya, E. Yarovaya
semanticscholar +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The road not taken: Could stress-specific mutations lead to different evolutionary paths?
PLoS Biology, 2017 Organisms often encounter stressful conditions, some of which damage their DNA. In response, some organisms show a high expression of error-prone DNA repair machinery, causing a temporary increase in the genome-wide mutation rate.
Deepa Agashe
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
An evolutionary model for GHz Peaked Spectrum Sources. Predictions for high frequency surveys [PDF]
, 1999 We have explored, in the general framework of the ``young source'' scenario, evolutionary models for GHz Peaked Spectrum (GPS) galaxies and quasars which reproduce the observed counts, redshift and peak frequency distributions of currently available ...
Danese, L. +4 more
core +1 more source