Results 61 to 70 of about 863,024 (318)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
mBioThe microbiome expresses a variety of functions that influence host biology. The range of functions depends on the microbiome’s composition, which can change during the host’s lifetime due to neutral assembly processes, host-mediated selection, and ...
Johannes Zimmermann +10 more
doaj +1 more source
The Curatorial Turn in the Darwin Year 2009
19, 2010 The concept of the ‘curatorial turn’ was originally coined by Daniel Birnbaum, director of the 2009 Venice Biennale, and denoted interest in the exhibition as an alternative to the book by contemporary philosophers such as Jean-François Lyotard and Bruno
Julia Voss
doaj +2 more sources
Pluralism in evolutionary theory [PDF]
Journal of Evolutionary Biology, 2005 The review by Waxman and Gavrilets illustrates the collision of different mindsets in evolutionary theory. These differences originate from the awe-inspiring complexity of the evolutionary process itself: evolutionary understanding critically depends on processes at many biological levels.
Dieckmann, U., Doebeli, M.
openaire +3 more sources
Evolutionary stability in quantum games
, 2007 In evolutionary game theory an Evolutionarily Stable Strategy (ESS) is a refinement of the Nash equilibrium concept that is sometimes also recognized as evolutionary stability. It is a game-theoretic model, well known to mathematical biologists, that was
Cheon, Taksu, Iqbal, Azhar
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Temporal and dimensional effects in evolutionary graph theory
, 2007 The spread in time of a mutation through a population is studied analytically and computationally in fully-connected networks and on spatial lattices. The time, t_*, for a favourable mutation to dominate scales with population size N as N^{(D+1)/D} in D ...
C. J. Paley +10 more
core +1 more source
Problems with Using Evolutionary Theory in Philosophy [PDF]
, 2017 Does science move toward truths? Are present scientific theories (approximately) true? Should we invoke truths to explain the success of science? Do our cognitive faculties track truths? Some philosophers say yes, while others say no, to these questions.
A Bird +16 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Generalized Price Equation: Forces That Change Population Statistics
Frontiers in Ecology and Evolution, 2020 The Price equation partitions the change in the expected value of a population measure. The first component describes the partial change caused by altered frequencies. The second component describes the partial change caused by altered measurements.
Steven A. Frank, William Godsoe
doaj +1 more source