Results 81 to 90 of about 6,349,669 (299)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Evolutionary stability: cooperation, mutation, and equilibrium [Game theory]
, 2013 Educação Superior::Ciências Exatas e da Terra::Ciência da ComputaçãoPresents a classo about the evolution and game theory, and introduce the concept of evolutionary stability.
Polak, Ben
core +2 more sources
Tradurre evoluzionismi. Due libri di Dan Sperber e Patrick Tort in italiano
Lingue Culture Mediazioni, 2020 Not all Darwinisms are alike. Biological Darwinism is by now an established fact: its basis (first developed in The Origin of Species, 1859), natural selection, seems to have resisted so far to any serious falsification attempt.
Fabio Regattin
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
How Developmental is Evolutionary Developmental Biology? [PDF]
, 2002 Evolutionary developmental biology (evo-devo) offers both an account of developmental processes and also new integrative frameworks for analyzing interactions between development and evolution.
Jason Scott Robert, Robert, Jason Scott
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The evolutionary theory of the firm: Routines, complexity and change [PDF]
This paper provides an overview on the evolutionary theory of the firm. The specific feature of the evolutionary approach is that it explains the adaptive behaviors of firms through the tension between innovation and selection.
Werner Hölzl
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Outlining the distinguishing characteristics of an evolutionary theory of innovation [PDF]
This paper discusses notions of theory in relation to evolutionary understandings of innovation. It starts by empirically demonstrating the relevance of evolutionary perspectives – broadly defined – for understanding the “basics of what’s going on” in ...
Tommy Clausen
core
(Re‐) Defining evolutionary medicine
Ecology and Evolution, 2020 The applicability of evolutionary biology principles to diseases has been largely questioned by the medical field. While Evolutionary Medicine (EM) developed in part to lessen this gap, EM is an independent field from both evolution and medicine, whose ...
Jacqueline Moltzau Anderson +1 more
doaj +1 more source