Results 31 to 40 of about 178,017 (315)

Evolution and diversification of Ca2+/H+ exchangers: insights into karst-plant adaption to high-calcium environment

BMC Plant Biology
Background Calcium (Ca2+) is a critical mineral essential for plant growth, development, and signal transduction. The CAX (Ca²⁺/H⁺ exchanger) family represents a group of key transmembrane transporters that mediate Ca2+ transport and homeostasis, thereby
Endian Yang, Yi Zhang, Hongwen Huang, Chen Feng   +3 more
doaj   +1 more source

Kiwifruit in the Omics Age: Advances in Genomics, Breeding, and Beyond

Plants
The kiwifruit, Actinidia genus, has emerged as a nutritionally rich and economically significant crop with a history rooted in China. This review paper examines the global journey of the kiwifruit, its genetic diversity, and the role of advanced breeding
Mian Faisal Nazir, Jinpeng Lou, Yu Wang, Shuaiyu Zou, Hongwen Huang   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Combined full-length transcriptomic and metabolomic analysis reveals the molecular mechanisms underlying nutrients and taste components development in Primulina juliae

BMC Genomic Data
Background Primulina juliae has recently emerged as a novel functional vegetable, boasting a significant biomass and high calcium content. Various breeding strategies have been employed to the domestication of P. juliae.
Yi Zhang, Endian Yang, Qin Liu, Jie Zhang, Chen Feng   +4 more
doaj   +1 more source

Evolutionary pattern of Macaca fascicularis in Southeast Asia inferred using Y-chromosomal gene

BMC Ecology and Evolution, 2021
Background We analyzed a combined segment (2032-bp) of the sex-determining region and the testis-specific protein of the Y-chromosome (Y-DNA) gene to clarify the gene flow and phylogenetic relationships of the long-tailed macaques (Macaca fascicularis ...
Jeffrine J. Rovie-Ryan, Faisal Ali Anwarali Khan, Mohd Tajuddin Abdullah   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chromosome-level genome assembly of Malus niedzwetzkyana, the mother of Rosybloom crabapple

Scientific Data
Malus niedzwetzkyana (MN) is the mother of Rosybloom hybrids, ornamental crabapples with red and purple flowers. We present a high-quality chromosome-scale genome for MN with a size of 672.64 Mb, anchored to 17 chromosomes and with a high BUSCO ...
Ruizhen Wang, Jian Quan, Boyang Liu, Yu Wei, Hengxing Liu, Ran He, Ling Guo, Leiming Dong   +7 more
doaj   +1 more source

Comparison of Gut Microbial Ecology of Captive and Wild Water Deer for Understanding Mammalian Ecology and Conservation

Diversity
The water deer, although an internationally endangered species, is designated as a nuisance wild animal in South Korea and occupies a unique ecological niche. Studying the gut microbiome of this species is crucial for understanding its ecology.
Chang-Eon Park, Hee-Cheon Park
doaj   +1 more source

An EAGLE’s view of ex situ galaxy growth [PDF]

Monthly Notices of the Royal Astronomical Society, 2020
ABSTRACT Modern observational and analytical techniques now enable the direct measurement of star formation histories and the inference of galaxy assembly histories. However, current theoretical predictions of assembly are not ideally suited for direct comparison with such observational data.
Thomas A Davison, Mark A Norris, Joel L Pfeffer, Jonathan J Davies, Robert A Crain   +4 more
openaire   +4 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source