Ian D Pavord,1 Paul W Jones,2 Pierre-Régis Burgel,3 Klaus F Rabe4,5 1Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; 2Division of Clinical Science, St George’s, University of London, London, UK;
Pavord ID, Jones PW, Burgel PR, Rabe KF
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Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. Severe exacerbations are related to a significantly worse survival outcome.
Christian Viniol, Claus F. Vogelmeier
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Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST) [PDF]
BACKGROUND: Recurrent bronchiectasis exacerbations are related to deterioration of lung function, progression of the disease, impairment of quality of life, and to an increased mortality.
A Spinou +26 more
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Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma : results from two phase 3, randomised, double-blind, placebo-controlled trials [PDF]
BACKGROUND: Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients with uncontrolled severe asthma and ...
Adir, Yochai +13 more
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This case is targeted to emergency medicine residents of all levels.Shortness of breath (SOB) is one of the top ten most common chief complaints seen in the Emergency Department, accounting for close to 10% of presenting complaints.1 An acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a frequent culprit, accounting for roughly 15.
Pappas, Dominic, Vempati, Amrita
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The Association Between Rate and Severity of Exacerbations in Chronic Obstructive Pulmonary Disease: An Application of a Joint Frailty-Logistic Model. [PDF]
Exacerbations are a hallmark of chronic obstructive pulmonary disease (COPD). Evidence suggests the presence of substantial between-individual variability (heterogeneity) in exacerbation rates.
Albert, Richard +8 more
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Early versus delayed pulmonary rehabilitation:A randomized controlled trial – Can we do it? [PDF]
Providing outpatient pulmonary rehabilitation (PR) following hospitalization for an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been found to improve exercise capacity, quality of life and a reduction in unplanned hospital ...
Revitt, Olivia +2 more
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Heterogeneity of IPF exacerbations [PDF]
Heterogeneity of IPF ...
Ramakrishnan, Sanjay, Bafadhel, Mona
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Combination formoterol and inhaled steroid versus beta(2)-agonist as relief medication for chronic asthma in adults and children (Review) [PDF]
Background Formoterol has a fast onset of action and can therefore be used to relieve symptoms of asthma. A combination inhaler can deliver formoterol with different doses of inhaled corticosteroid; when used as a reliever both drugs will be delivered ...
Adams +46 more
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Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations [PDF]
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A Singanayagam +43 more
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