Results 31 to 40 of about 264,900 (297)

Can COPD Exacerbations Be Picked Up Early via a Weekly Medication Question Through a Smartphone Application?

Frontiers in Rehabilitation Sciences, 2022
BackgroundExacerbations affect the disease trajectory of patients with COPD and result in an acute drop of functional status and physical activity. Timely detection of exacerbations by non-medical healthcare professionals is needed to counteract this ...
Astrid Blondeel, Heleen Demeyer, Heleen Demeyer, Sofie Breuls, Marieke Wuyts, Lies Glorie, Nikolaas De Maeyer, Wim Janssens, Wim Janssens, Thierry Troosters   +9 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Percent Recovery Index Predicts Poor Asthma Control and Exacerbation in Adults

Journal of Asthma and Allergy, 2023
Lisha Kuang,1,* Cheng Ren,2,* Xiuqing Liao,2 Xiaobin Zhang,2 Xuegang Zhou2 1Department of Health Management Center, Chongqing University Fuling Hospital, Chongqing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine,
Kuang L, Ren C, Liao X, Zhang X, Zhou X
doaj  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The disruptive effects of COPD exacerbation-associated factors on epithelial repair responses

Frontiers in Immunology
IntroductionExacerbations of chronic obstructive pulmonary disease (COPD) increase mortality risk and can lead to accelerated loss of lung function. The increased inflammatory response during exacerbations contributes to worsening of airflow limitation ...
Rosa K. Kortekaas, Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Rocío Fuentes-Mateos, Rocío Fuentes-Mateos, Roël van Orsoy, Roël van Orsoy, Nakaa Al-Alyan, Nakaa Al-Alyan, Janette K. Burgess, Janette K. Burgess, Reinoud Gosens, Reinoud Gosens   +12 more
doaj   +1 more source

Key toolkits of non-pharmacological management in COPD: during and beyond COVID-19

Frontiers in Bioscience-Landmark, 2021
Individuals with COPD are at higher risk of severe disease and mortality if they contract COVID-19. Shielding and social distancing have negatively impacted the delivery of routine care for COPD patients, which should be maintained to avoid further ...
Jaber S. Alqahtani, Saeed M Alghamdi, Abdulelah M Aldhahir, Malik Althobiani, Tope Oyelade   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Diaphragm Ultrasound is an Imaging Biomarker that Distinguishes Exacerbation Status from Stable Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2022
Tai Joon An,1 Yeun Jie Yoo,2 Jeong Uk Lim,1 Wan Seo,3 Chan Kwon Park,1 Chin Kook Rhee,4 Hyoung Kyu Yoon1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St.
An TJ, Yoo YJ, Lim JU, Seo W, Park CK, Rhee CK, Yoon HK   +6 more
doaj  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

B-type natriuretic peptide as a predictor of severity in admitted patients with acute exacerbation of COPD

The Egyptian Journal of Bronchology, 2019
Background patients with acute AECOPD show an abrupt worsening of baseline ventricular function and pulmonary hypertension, using clear predictors or markers for severity in such patients is critical to be early stratified and properly managed.
Nasser K. Abdelnaby, Hassan A. Shabana, Waleed R. Arafat   +2 more
doaj   +1 more source