Results 41 to 50 of about 340,431 (244)

Exacerbations [PDF]

Chest, 2002
Some patients with COPD are prone to frequent exacerbations, which are an important determinant of health status. Such patients have elevated airway cytokine levels, suggesting the presence of increased inflammation that may increase their susceptibility to exacerbation. The inflammatory response during a COPD exacerbation is variable, but increases in
openaire   +3 more sources

Risk factors for acute exacerbations of COPD in a primary care population: A retrospective observational cohort study [PDF]

, 2014
Objectives: To evaluate risk factors associated with exacerbation frequency in primary care. Information on exacerbations of chronic obstructive pulmonary disease (COPD) has mainly been generated by secondary care-based clinical cohorts.
Hawkins, A, Müllerová, H, Quint, J, Shukla, A   +3 more
core   +3 more sources

Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma : results from two phase 3, randomised, double-blind, placebo-controlled trials [PDF]

, 2020
BACKGROUND: Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients with uncontrolled severe asthma and ...
Adir, Yochai, Bernstein, Jonathan A, Brusselle, Guy, Castro, Mario, Garin, Margaret, Hickey, Lisa, Humbert, Marc, Jacobs, Joshua, Marsteller, Douglas A, Maspero, Jorge Fernando, McElhattan, Jennifer, Murphy, Kevin, Vanlandingham, Rebecca, Virchow, J Christian   +13 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation [PDF]

, 2013
Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist.
A Papi, A van de Stolpe, AC Palmenberg, Alan Carruthers, Alexandra Nikonova, Alison Humbles, AM Randi, Andrew J. Leishman, Andrew Pekosz, CR Uncapher, D Wat, DC Pevear, DE Staunton, DJ Jackson, DJ Jackson, DJ Jackson, FG Hayden, FG Hayden, Gary R. McLean, J Bizzintino, J Corren, J Garbino, J Las Heras, JE Gern, JE Prince, Jie Zhu, JM Greve, Katherine A. Vousden, Katie Bernard, KB Weiss, KG Nicholson, Leila Gogsadze, Matthew A. Sleeman, Michael Dymond, MS Diamond, Musa Khaitov, Nathan W. Bartlett, Nicholas Glanville, NW Bartlett, P Mallia, Q Wang, Qing Zhu, R Fleischer, Rebecca Dunmore, RF Lemanske Jr, RH Dougherty, RM Owens, Roland Kolbeck, Ross P. Walton, RR Turner, Sebastian L. Johnston, SK Lau, SL Binford, Stephanie Traub, Ted Wells, Weidong Hao, YA Bochkov   +56 more
core   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Impact of exacerbations on COPD [PDF]

European Respiratory Review, 2010
Exacerbations of chronic obstructive pulmonary disease (COPD) determine disease-associated morbidity, mortality, resource burden and healthcare costs. Acute exacerbation care requirements range from unscheduled primary care visits to emergency room, inpatient or intensive care, generating significant costs in COPD.
openaire   +4 more sources

Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma [PDF]

, 2010
Background Formoterol is a long-acting beta(2)-agonist but because it has a fast onset of action it can also be used as a relief medication. Objectives To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting ...
Cates, CJ, Welsh, EJ
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Current GOLD recommendations and its implementation within hospitalised COPD patients in Malta [PDF]

, 2015
In 2012, Global Initiative for Chronic Obstructive Lung Disease (GOLD) revised their classification of Chronic Obstructive Pulmonary Disease patients, incorporating spirometry, symptoms and recent exacerbations.
Bilocca, David, Gauci, Jonathan, Mifsud, Maria, Montefort, Stephen, Yamagata, Kentaro   +4 more
core