Results 61 to 70 of about 283,135 (312)
Don’t Leave Without Them: Dispensing asthma medications to pediatric patients upon discharge is associated with decreased hospital readmissions [PDF]
INNOVATIONS in Pharmacy, 2012 Purpose: Asthma exacerbations are a leading cause of hospital and emergency department admissions at pediatric institutions. The objective of this study was to determine if patients who obtain discharge medications from a pediatric institution’s ...
Aleda M.H. Chen, Pharm.D.,M.S., Ph.D. +3 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Drugs in exacerbation of psoriasis
Journal of the American Academy of Dermatology, 1986 Drugs that have been associated with the precipitation or exacerbation of psoriasis include lithium, beta adrenergic receptor blocking agents, and antimalarials. The withdrawal of corticosteroids has been reported to activate pustular psoriasis. Nonsteroidal anti-inflammatory drugs, such as indomethacin, have recently been reported to exacerbate ...
E A, Abel +4 more
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study
, 2023 Yunlei Ma,1 Hanjun Zhao,2 Yinghao Su1 1Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 2Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University,
Ma Y, Su Y, Zhao H
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2019 Background Chronic obstructive pulmonary disease (COPD) is the third leading universal cause of mortality. Although chronic obstructive pulmonary disorder is primarily a chronic disease, a great number of patients complain of exacerbations.
Rasha M Hendy, Marwa E El-Naggar
doaj +1 more source
Impact of exacerbations on COPD [PDF]
European Respiratory Review, 2010 Exacerbations of chronic obstructive pulmonary disease (COPD) determine disease-associated morbidity, mortality, resource burden and healthcare costs. Acute exacerbation care requirements range from unscheduled primary care visits to emergency room, inpatient or intensive care, generating significant costs in COPD.
openaire +3 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
International Journal of COPD, 2022 Kjell Larsson,1 Karin Lisspers,2 Björn Ställberg,2 Gunnar Johansson,2 Florian S Gutzwiller,3 Karen Mezzi,3 Bine Kjoeller Bjerregaard,4 Leif Jorgensen,4 Hyewon Koo,5 Christer Janson6 1Integrative Toxicology, The National Institute of Environmental ...
Larsson K +9 more
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