Results 81 to 90 of about 242,368 (323)

B-type natriuretic peptide as a predictor of severity in admitted patients with acute exacerbation of COPD

The Egyptian Journal of Bronchology, 2019
Background patients with acute AECOPD show an abrupt worsening of baseline ventricular function and pulmonary hypertension, using clear predictors or markers for severity in such patients is critical to be early stratified and properly managed.
Nasser K. Abdelnaby, Hassan A. Shabana, Waleed R. Arafat   +2 more
doaj   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Annual and Post-Exacerbation Follow-Up of Asthma Patients in Clinical Practice – A Large Population-Based Study in Sweden

Journal of Asthma and Allergy, 2022
Hanna Sandelowsky,1– 3 Björn Ställberg,4 Fredrik Wiklund,5 Gunilla Telg,6 Sofie de Fine Licht,6 Christer Janson7 1Karolinska Institutet, Department of Medicine, Division of Clinical Epidemiology, Solna, Sweden; 2Karolinska Institutet, Department of ...
Sandelowsky H, Ställberg B, Wiklund F, Telg G, de Fine Licht S, Janson C   +5 more
doaj  

Role of mean platelet volume in patients with chronic obstructive pulmonary disease

The Egyptian Journal of Bronchology, 2016
Background and objective Stable chronic obstructive pulmonary disease (COPD) is associated with low-grade systemic inflammation as demonstrated by an increase in blood leukocytes, acute-phase proteins such as C-reactive protein, and inflammatory ...
Eman R. Ali
doaj   +1 more source

Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells

Frontiers in Cellular and Infection Microbiology, 2020
Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by mucus hypersecretion.
Ying Wang, Dennis K. Ninaber, Annemarie van Schadewijk, Pieter S. Hiemstra   +3 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

EAB-FL: Exacerbating Algorithmic Bias through Model Poisoning Attacks in Federated Learning [PDF]

Federated Learning (FL) is a technique that allows multiple parties to train a shared model collaboratively without disclosing their private data. It has become increasingly popular due to its distinct privacy advantages. However, FL models can suffer from biases against certain demographic groups (e.g., racial and gender groups) due to the ...
arxiv   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP

Journal of Inflammation Research, 2021
Haiyan Ge,1,* Xuanqi Liu,1,* Wenchao Gu,2 Xiumin Feng,3,4 Fengying Zhang,5 Fengfeng Han,6 Yechang Qian,7 Xiaoyan Jin,8 Beilan Gao,9 Li Yu,10 Hong Bao,11 Min Zhou,12 Shengqing Li,13 Zhijun Jie,14 Jian Wang,15 Zhihong Chen,16 Jingqing Hang,5 Jingxi
Ge H, Liu X, Gu W, Feng X, Zhang F, Han F, Qian Y, Jin X, Gao B, Yu L, Bao H, Zhou M, Li S, Jie Z, Wang J, Chen Z, Hang J, Zhang J, Zhu H   +18 more
doaj  

Integrating Latent Classes in the Bayesian Shared Parameter Joint Model of Longitudinal and Survival Outcomes [PDF]

arXiv, 2018
Cystic fibrosis is a chronic lung disease which requires frequent patient monitoring to maintain lung function over time and minimize onset of acute respiratory events known as pulmonary exacerbations. From the clinical point of view it is important to characterize the association between key biomarkers such as $FEV_1$ and time-to first exacerbation ...
arxiv