Results 91 to 100 of about 140,049 (297)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype

Clinical & Experimental Allergy, 2009
SummaryAsthma is a highly prevalent chronic respiratory disease affecting 300 million people world‐wide. A significant fraction of the cost and morbidity of asthma derives from acute care for asthma exacerbations. In the United States alone, there are approximately 15 million outpatient visits, 2 million emergency room visits, and 500 000 ...
Dougherty, R. H., Fahy, J. V.
openaire   +3 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Acute exacerbations of COPD: risk factors for failure and relapse

International Journal of COPD, 2017
Marco Mantero,1,2 Paola Rogliani,3 Marta Di Pasquale,1,2 Eva Polverino,4 Ernesto Crisafulli,5 Monica Guerrero,6 Andrea Gramegna,1,2 Mario Cazzola,3 Francesco Blasi1,2 1Department of Pathophysiology and Transplantation, Università degli Studi di ...
Mantero M, Rogliani P, Di Pasquale M, Polverino E, Crisafulli E, Guerrero M, Gramegna A, Cazzola M, Blasi F   +8 more
doaj  

Asthma and obesity – A prospective observational study of bariatric surgery’s effect on asthma control [PDF]

Revista Portuguesa de Imunoalergologia
Introduction: The relationship between asthma and obesity is complex and multifactorial. Obesity is a risk factor for asthma and is associated with more severe disease, poor response to treatment, and more frequent exacerbations.
Mariana Bragança, Luís Amaral, Hugo Santos Sousa, Fernando Resende, André Pinho, John Preto, Eduardo Lima da Costa, José Luís Plácido   +7 more
doaj   +1 more source

Lung microbiology and exacerbations in COPD

, 2012
Victoria Beasley,2 Priya V Joshi,2 Aran Singanayagam,1,2 Philip L Molyneaux,1,2 Sebastian L Johnston,1,2 Patrick Mallia,1,21National Heart and Lung Institute, Imperial College London, London, UK; 2Imperial College Healthcare NHS Trust, London, UKAbstract:
Johnston SL, Joshi PV, Beasley V, Mallia P, Singanayagam A, Molyneaux PL   +5 more
core  

Impact and prevention of severe exacerbations of COPD: a review of the evidence [PDF]

, 2017
David MG Halpin,1 Marc Miravitlles,2 Norbert Metzdorf,3 Bartolomé Celli4 1Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK; 2Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades ...
Metzdorf, N., David MG Halpin, Marc Miravitlles, Miravitlles, M., Miravitlles M, Metzdorf N, Celli B, Halpin DMG, Norbert Metzdorf, Halpin, David M, Bartolomé Celli, Celli, B.   +11 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Healthcare Resource Utilization, Exacerbations, and Readmissions Among Medicare Patients with Chronic Obstructive Pulmonary Disease After Long-Acting Muscarinic Antagonist Therapy Initiation with Soft Mist versus Dry Powder Inhalers

International Journal of COPD, 2020
David Singer,1 Lindsay GS Bengtson,2 Caitlin Elliott,2 Ami R Buikema,2 Jessica Franchino-Elder1 1Health Economics and Outcomes Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA; 2Health Economics and Outcomes Research, Optum, Eden ...
Singer D, Bengtson LG, Elliott C, Buikema AR, Franchino-Elder J   +4 more
doaj