Results 101 to 110 of about 181,704 (312)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Diaphragmatic Movement at Rest and After Exertion: A Non-Invasive and Easy to Obtain Prognostic Marker in COPD

International Journal of COPD, 2022
Evgeni Mekov,1 Nikolay Yanev,2 Nedelina Kurtelova,2 Teodora Mihalova,2 Adelina Tsakova,3 Yordanka Yamakova,4 Marc Miravitlles,5 Rosen Petkov2 1Department of Occupational Diseases, Medical University Sofia, Sofia, Bulgaria; 2Department of Pulmonary ...
Mekov E, Yanev N, Kurtelova N, Mihalova T, Tsakova A, Yamakova Y, Miravitlles M, Petkov R   +7 more
doaj  

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. [PDF]

, 2013
BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and cough. Treatment with inhaled steroids and bronchodilators often results in good control of symptoms, prevention of ...
Ferrara, G, Karner, C, Kew, KM, Mindus, SM   +3 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD [PDF]

, 2014
Dirkje S Postma,1 Nicolas Roche,2 Gene Colice,3 Elliot Israel,4 Richard J Martin,5 Willem MC van Aalderen,6 Jonathan Grigg,7 Anne Burden,8 Elizabeth V Hillyer,8 Julie von Ziegenweidt,8 Gokul Gopalan,9 David Price8,10 1University of Groningen, Department ...
Burden, A, Colice, G, Gopalan, G, Grigg, J, Hillyer, EV, Israel, E, Martin, RJ, Postma, DS, Price, D, Roche, N, van Aalderen, WMC, von Ziegenweidt, J   +11 more
core   +6 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Spirometry, the St. George’s Respiratory Questionnaire, and other clinical measures as predictors of medical costs and COPD exacerbation events in a prospective cohort

Southwest Respiratory and Critical Care Chronicles, 2015
Purpose:We conducted a prospective clinical cohort study of 300 established COPD patients randomly recruited from one managed care system to examine how well a battery of spirometry, exercise, and health status measures, including the St.
Douglas W Mapel, Melissa Roberts
doaj  

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria [PDF]

, 2013
Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Bowler, RP, Chu, HW, Jiang, D, Schnell, C, Wenzel, SE, Wu, Q   +5 more
core   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

FENOMA Study: Achieving Full Control in Patients with Severe Allergic Asthma

Journal of Asthma and Allergy, 2020
Sheila Cabrejos,1 Ana Moreira,2 Andreina Ramirez,2 Santiago Quirce,3 Gregorio Soto Campos,4 Ignacio Dávila,5 Paloma Campo6 1Allergy Service, Hospital Rafael Mendez de Lorca, Murcia, Spain; 2Novartis Farmacéutica, Barcelona, Spain ...
Cabrejos S, Moreira A, Ramirez A, Quirce S, Soto Campos G, Dávila I, Campo P   +6 more
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