Results 41 to 50 of about 140,049 (297)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bronchiectasis in COPD patients: more than a comorbidity?
International Journal of COPD, 2017 Miguel Angel Martinez-Garcia,1,2 Marc Miravitlles2,3 1Pneumology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain; 2CIBER de Enfermedades Respiratorias (CIBERES), Spain; 3Pneumology Department, Hospital Universitari Vall d ...
Martinez-Garcia MA, Miravitlles M
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The role of airway infection in chronic obstructive pulmonary disease [PDF]
, 2006 PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core +4 more sources
Human Rhinovirus at Naturally Occurring COPD Exacerbation [PDF]
, 2015 Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the lung caused by an abnormal response to particles and noxious gases, primarily cigarette smoke.
George, SN
core
Фармакоэкономика, 2022 Objective: to evaluate the pharmacoeconomic effectiveness of the use of a fixed double combination of tiotropium bromide + olodаterol in order to treat chronic obstructive pulmonary disease (COPD) in comparison with less expensive monotherapy with long ...
S. К. Zyryanov, I. N. Dyakov
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Viruses and asthma exacerbations [PDF]
Thorax, 1998 For many years general opinion has been that upper respiratory viruses were the cause of the common cold but were able to produce serious complications only in infants, the elderly, and immunocompromised subjects. Although a connection between upper respiratory infections and asthma had long been recognised, the potential importance of the association ...
N G, Papadopoulos, S L, Johnston
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Women manifest more severe COPD symptoms across the life course
International Journal of COPD, 2018 Dawn L DeMeo,1 Sreeram Ramagopalan,2 Abhishek Kavati,3 Ashok Vegesna,3 Meilan K Han,4 Anthony Yadao,5 Teresa K Wilcox,2 Barry J Make6 On behalf of COPDGene Investigators 1Channing Division of Network Medicine and the Pulmonary and Critical Care ...
DeMeo DL +7 more
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