Results 91 to 100 of about 1,376,473 (288)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Penetrance rate estimation in autosomal dominant conditions
Genetics and Molecular Biology, 2012 Accurate estimates of the penetrance rate of autosomal dominant conditions are important, among other issues, for optimizing recurrence risks in genetic counseling. The present work on penetrance rate estimation from pedigree data considers the following
Paulo A. Otto, Andréa R.V.R. Horimoto
doaj
Approximate Estimate for Exact Logistic Regression
Japanese journal of applied statistics, 2007 ロジスティック回帰モデルを利用する際,最尤法によりパラメータ推定を行うのが一般的である.しかし,最尤推定量は完全分離または準完全分離の場合に存在しないことが知られている.また,発現確率が極端に小さい(または大きい)場合やパラメータ数に比べて標本サイズが小さい場合も妥当でないことが知られている.このような状況において,精確ロジスティック回帰推定法が有用であると言われている.しかし,すべての統計ソフトで精確ロジスティック回帰推定法を実施できるわけではない.Firth(1993)は最尤推定量のバイアスを取り除く方法を提案したが,完全分離または準完全分離に近い状態での検証は十分行われていない.本報告の目的は,完全分離または準完全分離に近い状態において ...
Masayuki Ohkura, Toshinari Kamakura
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
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Coercive solvability of the nonlocal boundary value problem for parabolic differential equations
Abstract and Applied Analysis, 2001 The nonlocal boundary value problem, v′(t)+Av(t)=f(t)(0≤t≤1),v(0)=v(λ)+μ ...
A. Ashyralyev +2 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Journal of Numerical Analysis and Approximation Theory, 2008 In this paper, Voronovskaja-type results with quantitative upper estimates and the exact orders in simultaneous approximation by some complex Kantorovich-type polynomials and their iterates in compact disks in \(\mathbb{C}\) are obtained.
Sorin G. Gal
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Journal of Taibah University for Science, 2019 This article investigates the Euler-Maruyama approximation procedure for stochastic differential equations in the framework of G-Browinian motion with non-linear growth and non-Lipschitz conditions.
Faiz Faizullah +3 more
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Exact rates in density support estimation
Journal of Multivariate Analysis, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Biau, Gérard +2 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source