Results 71 to 80 of about 323,983 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

On sample size estimation of the arithmetic mean of a lognormal distribution with and without type I

Revista Colombiana de Estadística, 1997
This article presents several formulas to approximate the required sample size to estimate the arithmetic mean of a lognormal distribution with desired accuracy and confidence under and without the presence of type I censoring to the left.
Pérez Adriana, Lefante John J.
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Risk Estimates From an Online Risk Calculator Are More Believable and Recalled Better When Expressed as Integers

Journal of Medical Internet Research, 2011
BackgroundOnline risk calculators offer different levels of precision in their risk estimates. People interpret numbers in varying ways depending on how they are presented, and we do not know how the number of decimal places displayed might influence ...
Witteman, Holly O, Zikmund-Fisher, Brian J, Waters, Erika A, Gavaruzzi, Teresa, Fagerlin, Angela   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Penetrance rate estimation in autosomal dominant conditions

Genetics and Molecular Biology, 2012
Accurate estimates of the penetrance rate of autosomal dominant conditions are important, among other issues, for optimizing recurrence risks in genetic counseling. The present work on penetrance rate estimation from pedigree data considers the following
Paulo A. Otto, Andréa R.V.R. Horimoto
doaj  

An exact subspace method for fundamental frequency estimation [PDF]

2013 IEEE International Conference on Acoustics, Speech and Signal Processing, 2013
In this paper, an exact subspace method for fundamental frequency estimation is presented. The method is based on the principles of the MUSIC algorithm, wherein the orthogonality between the signal and and noise subspace is exploited. Unlike the original MUSIC algorithm, the new method uses an exact measure of the angles between the subspaces.
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Coercive solvability of the nonlocal boundary value problem for parabolic differential equations

Abstract and Applied Analysis, 2001
The nonlocal boundary value problem, v′(t)+Av(t)=f(t)(0≤t≤1),v(0)=v(λ)+μ ...
A. Ashyralyev, A. Hanalyev, P. E. Sobolevskii   +2 more
doaj   +1 more source