Results 91 to 100 of about 2,188,866 (304)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of Taibah University for Science, 2019 This article investigates the Euler-Maruyama approximation procedure for stochastic differential equations in the framework of G-Browinian motion with non-linear growth and non-Lipschitz conditions.
Faiz Faizullah +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Bootstrap inference in a linear equation estimated by instrumental variables [PDF]
We study several tests for the coefficient of the single right-hand-side endogenous variable in a linear equation estimated by instrumental variables.
James Mackinnon, Russell Davidson
core +4 more sources
Thin obstacle problem: Estimates of the distance to the exact solution
, 2018 We consider elliptic variational inequalities generated by obstacle type problems with thin obstacles. For this class of problems, we deduce estimates of the distance (measured in terms of the natural energy norm) between the exact solution and any ...
Repin S.I., Apushkinskaya D.E.
core +2 more sources
Penetrance rate estimation in autosomal dominant conditions
Genetics and Molecular Biology, 2012 Accurate estimates of the penetrance rate of autosomal dominant conditions are important, among other issues, for optimizing recurrence risks in genetic counseling. The present work on penetrance rate estimation from pedigree data considers the following
Paulo A. Otto, Andréa R.V.R. Horimoto
doaj
Journal of Medical Internet Research, 2011 BackgroundOnline risk calculators offer different levels of precision in their risk estimates. People interpret numbers in varying ways depending on how they are presented, and we do not know how the number of decimal places displayed might influence ...
Witteman, Holly O +4 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Estimating exact form of generalisation errors
, 1999 A novel approach to estimate generalisation errors of the simple perceptron of the worst case is introduced. It is well known that the generalisation error of the simple perceptron is of the form d/t with an unknown constant d which depends only on the dimension of inputs, where t is the number of learned examples.
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source