Results 71 to 80 of about 76,814 (294)

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Simulating pseudotruss excavating part of excavators

Vestnik MGSU, 2019
Introduction. Single-dipper hydraulic excavators are becoming widely used multifunctional machines. Upgrading the machine as a whole and its assemblies is an actual problem to be solved with the aim of reducing material consumption and increasing stability and throughput.
Oleg A. Zotov, Dmitriy Yu. Gustov
openaire   +2 more sources

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Equipment Combination Model for Effective Excavation Work for Urban High Rise Buildings

Journal of Asian Architecture and Building Engineering, 2017
The excavation work for constructing urban high-rise buildings is narrow and deep, limiting the mobility of equipment. In addition, the productivity of excavation work varies according to the type and amount of equipment used. Therefore, a combination of
Donghoon Lee, Jun-Young Park, Sunkuk Kim
doaj   +1 more source

Wide Linearity Range and Rapid‐Response Tactile Sensor Inspired by Parallel Structures

Advanced Science, EarlyView.
Inspired by parallel structures, a composite tactile sensor design is proposed using parallel elastomer integration, developing two novel sensors. This strategy optimizes the force‐electric response and viscoelastic hysteresis of the conductive composite, achieving a balanced enhancement of linear sensing range and fast response.
Weihua Gao, Jiantao Yao, Xianhe Yu, Guoliang Ma, Dakai Wang, Hongnian Yu, Zhiwu Han, Luquan Ren   +7 more
wiley   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Estrategias de excavación y datación de arquitectura pública temprana. El caso de Cerro Lampay

Bulletin de l'Institut Français d'Études Andines, 2008
The design of excavations at Cerro Lampay, as well as the strategy to recover organic samples for 14C analysis are presented in detail, noting the potentialities of a methodology where field options are closely linked with clear-cut and specific research
Rafael Vega-Centeno Sara-Lafosse
doaj   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

Forensic excavations and burials in Uruguay, 2004–10

Human Remains and Violence, 2016
This article will describe the contemporary scientific techniques used to excavate and identify the dead bodies of disappeared detainees from the Uruguayan dictatorship.
Jose López Mazz
doaj   +1 more source

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach

Advanced Science, EarlyView.
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You, Hao Yang, Yueyan Zhao, Xiaoning Wang, Shuaijie Wei, Ning Chen, Yulan Zhang, Luxian Liu, Wei Qian, Shufen Li, Wujun Gao   +10 more
wiley   +1 more source