Results 71 to 80 of about 234,477 (336)
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
Justification of efficient options of fully-mechanized extraction of pitch coal at Kuang Khan Mine
Горные науки и технологии, 2016 Currently, the Vinacomin company actively mechanizes coal mining processes, developing process solutions for coal mining in complicated geological conditions.
N. I. Abramkin, Duc Thang Pham
doaj +1 more source
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Advanced Science, EarlyView.During charge transport, photogenerated carriers exchange energy with lattice vibrations, influencing photocatalytic performance. The deuteration strategy enhances exciton dissociation and suppresses non‐radiative energy loss, significantly improving photocatalytic hydrogen evolution.
Hongli Sun +13 more
wiley +1 more source
MdHSFA2 enhances heat stress tolerance through promoting the MdGolS4 transcription in apple
Scientific ReportsWith global climate change, extremely high temperatures are occurring frequently during summer, seriously affecting development of the apple industry.
Mohan Li +7 more
doaj +1 more source
MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection
Advanced Science, EarlyView.MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani +6 more
wiley +1 more source
BuildingsThe development trend of urban underground space towards deep and large three-dimensional foundation pit projects in complex environments faces the challenges of deformation and instability of supporting structures, strong sensitivity of the surrounding ...
Chao Guo +3 more
doaj +1 more source
First-year nest growth in the leaf-cutting ants Atta bisphaerica and Atta sexdens rubropilosa
Sociobiology, 2014 The majority of ants construct nests underground to maintain environmental conditions favorable to the development of immature and adult individuals. But little is known about nest growth.
Sandra Cardoso +3 more
doaj +1 more source
Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries
Advanced Science, EarlyView.While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang +3 more
wiley +1 more source