Results 71 to 80 of about 325,651 (334)

Excavations at Gellygaer [PDF]

The Classical Review, 1910
n ...
openaire   +2 more sources

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Les artisans africains : étude sociale et organisation du travail

Antiquités Africaines, 2016
The epigraphic inventory of the Latin inscriptions mentioning craftsmen discovered in Algeria allows presenting a first social study of the African artifices.
Touatia Amraoui
doaj   +1 more source

A time-dependent anisotropic model for argillaceous rocks: application to an underground excavation in Callovo-Oxfordian claystone [PDF]

, 2017
The paper presents a constitutive model for argillaceous rocks, developed within the framework of elastoplasticity, that includes a number of features that are relevant for a satisfactory description of their hydromechanical behaviour: anisotropy of ...
Gens Solé, Antonio, Mánica Malcom, Miguel Ángel, Ruiz Restrepo, Daniel Felipe, Vaunat, Jean   +3 more
core   +2 more sources

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Discovery of candidate genes involved in ethylene biosynthesis and signal transduction pathways related to peach bud cold resistance

Frontiers in Genetics
Background: Low temperature pose significant challenges to peach cultivation, causing severe damage to peach buds and restricting production and distribution.
Wenqian Xia, Yupeng Yang, Chenguang Zhang, Chenguang Zhang, Chunsheng Liu, Chunsheng Liu, Kun Xiao, Kun Xiao, Xiao Xiao, Xiao Xiao, Junkai Wu, Junkai Wu, Yanhong Shen, Yanhong Shen, Libin Zhang, Libin Zhang, Libin Zhang, Kai Su, Kai Su, Kai Su   +19 more
doaj   +1 more source

Local availability and long-range trade: the worked stone assemblage [PDF]

, 2012
Inter disciplinary study of major excavation assemblage from Norse settlement site in Orkney.
Barrett, J., Batey, C., Breckenridge, F., Bunbury, J., Forster, A., Gaunt, G., Jones, R.E.   +6 more
core  

Excavations at Nippur [PDF]

Scientific American, 1901
n ...
openaire   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source