Results 71 to 80 of about 465,954 (329)

A radiocarbon database for Scottish archaeological samples [PDF]

open access: yes, 2000
For the majority of dating laboratories and their respective user communities, the journal Radiocarbon is no longer regarded as the medium for primary publication of radiocarbon measurements.
Ashmore, P.J.   +2 more
core   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

open access: yesAdvanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi   +13 more
wiley   +1 more source

(Pre) Iron Age Burials of Thandikudi, Tamil Nadu

open access: yesAncient Asia, 2015
Thandikudi, one of the major villages in the Lower Palani Hills occupies a unique position as this village was well connected by major trade routes. The archaeological vestiges unearthed here have clearly attested that it was
RaNa Kumaran, M Saranya
doaj   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

open access: yesAdvanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou   +22 more
wiley   +1 more source

Greenhouse Gas Emissions from Excavation on Residential Construction Sites

open access: yesConstruction Economics and Building, 2014
Despite considerable research concerning the manifestation of greenhouse gases in the usage of buildings, little has been done concerning emissions arising from the construction process itself.
Perry Forsythe, Grace Ding
doaj   +1 more source

Recent excavations along the Yobe valley [PDF]

open access: yes, 2006
The Yobe valley is one of the many refugia that dotted the Chad basin after the commencement of the desiccation of the Sahara. It hypothetically must have been attractive to the population that had to move away from the aridized zone in search of ...
Hambolu, Musa O.
core  

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu   +14 more
wiley   +1 more source

Publishing Primary Data on the World Wide Web: Opencontext.org and an Open Future for the Past [PDF]

open access: yes, 2007
More scholars are exploring forms of digital dissemination, including open access (OA) systems where content is made available free of charge. These include peer -reviewed e -journals as well as traditional journals that have an online presence.
Eric C. Kansa
core  

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

open access: yesAdvanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li   +7 more
wiley   +1 more source

Discovery of candidate genes involved in ethylene biosynthesis and signal transduction pathways related to peach bud cold resistance

open access: yesFrontiers in Genetics
Background: Low temperature pose significant challenges to peach cultivation, causing severe damage to peach buds and restricting production and distribution.
Wenqian Xia   +19 more
doaj   +1 more source

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