Results 71 to 80 of about 949,321 (287)

2010 historic preservation awards [PDF]

open access: yes, 2010
The 2010 Historic Preservation Awards recognize the exceptional accomplishments in the preservation, rehabilitation, and interpretation of our architectural and cultural heritage.
South Carolina Office of the Governor   +2 more
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Aluminous phyllosilicates promote exceptional nanoscale preservation of biogeochemical heterogeneities in Archaean siliciclastic microbial mats

open access: yesNature Communications
Exceptional preservation of biogeochemical complexity in the Precambrian is largely limited to cherts, phosphates and shales; however, ancient fossils, including microbial mats and microbially induced sedimentary structures, also occur, more rarely, in ...
Keyron Hickman-Lewis   +13 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Governor’s Advisory Council for Exceptional Citizens Annual Report FY 2016

open access: yes, 2016
The Council’s mission is to provide leadership through advice and advocacy for the unmet needs of citizens of all ages who are exceptional*, in order to improve their lives.
Governor’s Advisory Council for Exceptional Citizens
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Structures Preserved by Exceptional Lie Algebras

open access: yes, 2003
For sp(n+2) and each exceptional Lie algebra a realization of depth 2 preserving the spaces spanned by a contact one-form and a bilinear form is given. For e_7 and e_6 a realization of depth 1 preserving a lightcone and the space spanned by a bilinear form is also presented. This makes the origin of the exceptions clear.
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

2013 historic preservation awards

open access: yes, 2013
The 2013 Historic Preservation Awards recognize the exceptional accomplishments in the preservation, rehabilitation, and interpretation of our architectural and cultural heritage.
South Carolina Office of the Governor   +2 more
core   +1 more source

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