Results 91 to 100 of about 949,321 (287)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Swiss ichthyosaurs: a review

Swiss Journal of Palaeontology
Switzerland is an ichthyosaur country: it has a rich record of marine reptile fossils, particularly the fish-shaped ichthyosaurs, and the according research.
Christian Klug, Timur Sivgin, Feiko Miedema, Beat Scheffold, Achim G. Reisdorf, Iwan Stössel, Erin E. Maxwell, Torsten M. Scheyer   +7 more
doaj   +1 more source

Corrigendum to ”Soutter, E. et al. (2024). Exceptional preservation of three-dimensional dunes on an ancient deep-marine seafloor: implications for sedimentary processes and depositional environments”

Sedimentologika
Corrigendum to ”Soutter, E. et al. (2024). Exceptional preservation of three-dimensional dunes on an ancient deep-marine seafloor: implications for sedimentary processes and depositional environments. Sedimentologika, 2(1), 1-18.
Euan Soutter, Ander Martínez-Doñate, Ian Kane, Miquel Poyatos-Moré, William Taylor, David M. Hodgson, Max J. Bouwmeester, Stephen Flint   +7 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Exceptional In Situ Preservation of Chondrocranial Elements in a Coniacian Mosasaurid from Colombia

Diversity
The first record of well-preserved chondrocranial elements in mosasaurids is here described. These elements are preserved in situ in a Coniacian skull found in north-central Colombia, inside a calcareous concretion.
María Eurídice Páramo-Fonseca, José Alejandro Narváez-Rincón, Cristian David Benavides-Cabra, Christian Felipe Yanez-Leaño   +3 more
doaj   +1 more source

The Palmetto Trust for Historic Preservation 2016 preservation award winners

, 2016
The 2016 Historic Preservation Awards recognize the exceptional accomplishments in the preservation, rehabilitation, and interpretation of our architectural and cultural heritage.
South Carolina Office of the Governor, Palmetto Trust for Historic Preservation, South Carolina Department of Archives and History   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Selective preservation of coleoid soft tissues in Lebanese Konservat-Lagerstätten

Swiss Journal of Palaeontology
The Upper Cretaceous Konservat-Lagerstätten of Lebanon—the Santonian-aged Sahel Aalma (Sahel Alma), and Cenomanian-aged Hjoula (Hadjoula, Hgula) and Haqel (Hakel, Haqil)—are world-renowned for their exceptional preservation of fossil organisms ...
Alison J. Rowe, Isabelle Rouget, Farid Saleh, Oulfa Belhadj, Marie Radepont, Dirk Fuchs, Pierre Abi Saad, Denis Audo, Pierre Gueriau, Isabelle Kruta   +9 more
doaj   +1 more source