Results 111 to 120 of about 1,272,486 (269)
Ekstatyczne eksplozje. Wajda, afekty i reparacja
Teksty Drugie, 2018 Andrzej Wajda’s films are based on visual excess. His method consists of a loose stringing together of contrasting images, which brings to mind Sergei Eisenstein’s notion of pathos. Both Wajda and Eisenstein conceive of affects as structures that work on
Sebastian Jagielski
doaj
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Desbordes. Vida, política y estéticas del exceso en Osvaldo Lamborghini y Diamela Eltit
Perífrasis. Revista de Literatura, Teoría y Crítica, 2016 Este artículo se propone analizar los modos como dos ficciones latinoamericanas contemporáneas, Sebregondi retrocede (1973) de Osvaldo Lamborghini e Impuesto a la carne (2010) de Diamela Eltit, problematizan las relaciones entre los saberes sobre los ...
María Cecilia Sánchez Idiart
doaj
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Restos de vida en Bajo este sol tremendo de Carlos Busqued
Perífrasis. Revista de Literatura, Teoría y Crítica, 2017 Este trabajo se propone analizar cómo la novela de Carlos Busqued Bajo este sol tremendo (2009) se apoya en la representación de vidas desechadas, basura y todo tipo de restos para instalarse en una tensión entre orden y exceso.
Marcos Seifert
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source