Results 51 to 60 of about 164,928 (306)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Open GeosciencesTo study the liquefaction problem of the dam foundation of an ultra-deep overburden in the strong earthquake area, a large-scale shaking table model test is carried out based on a 500 m rockfill dam project on an ultra-deep overburden.
Xing Yang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Determining the end of primary consolidation parameters based on settlement and excess pore water pressure [PDF]
Archives of Civil EngineeringThe multiple-stage loading with reloading at EOP tests were carried out on two high-plasticity remoulded clays. One percentage of the initial value of an excess pore water pressure has been adopted as a reference for the end of the primary consolidation ...
Bartłomiej Szczepan Olek
doaj +1 more source
, 2015 A model for one-dimensional consolidation of a double-layered foundation considering the depth-dependent initial excess pore pressure and additional stress and time-dependent loading under different drainage conditions was presented in this study and its
Jun-hui Zhang +3 more
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Study of factors affecting shale gas adsorption by simplified local density-Peng–Robinson method
Energy Exploration & Exploitation, 2017 Shale gas has become an important source of natural gas, and a significant portion of gas in the reservoir exists in an adsorbed state. Thus, knowledge of gas adsorption behavior is important to estimate original gas in place and shale gas production. In
Wei Guo +4 more
doaj +1 more source