Results 61 to 70 of about 6,295,184 (295)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimizing virtual power plant coordination through locational marginal flexibility under network constraints

Scientific Reports
The transition toward deeply decarbonized energy systems requires optimization frameworks that can simultaneously capture long-term dynamics, operational reliability, and contractual stability while managing multiple forms of uncertainty.
Liye Xie, Guodong Li, Min Xu, Xiaoliang Dong, Zhongfu Tan   +4 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A real differential view of equilibrium real exchange rates and misalignments [PDF]

, 2000
This paper examines the interaction of G7 real exchange rates with real output and interest rate differentials. Using cointegration methods, we generally find a link between the real exchange rate and the real interest differential.
Hoffmann, Mathias, MacDonald, Ronald
core  

Faunal response to benthic and hyporheic sedimentation varies with direction of vertical hydrological exchange [PDF]

, 2014
1. Sedimentation and clogging of benthic and hyporheic zone substrates is increasingly being recognised as one of the greatest threats to the ecological integrity of riverine ecosystems globally. This ex-situ study examined the influence of sedimentation
Bo, Boano, Boulton, Boulton, Boulton, Brunke, Brunke, Bruno, Collins, Davy-Bowker, Descloux, Descloux, Descloux, Dole-Oliver, Dunbar, Evans, Extence, Fowler, Franken, Gayraud, Gledhill, Greig, Huettel, IBM Corp, Izagirre, Jones, Jones, Joyce, Kemp, Krause, Larned, Larson, MacNeil, MacNeil, Malcolm, Maridet, Navel, Olsen, Pacioglu, Packman, Packman, Pepin, Plenet, Ren, Richards, Robertson, Ryan, Sarriquet, Simpson, Studinski, Stump, Taylor, Walters, Wang, Weigelhofer, Wood, Wood, Xu, Zweig   +58 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Equivalence of Nonstatic Two-Pion-Exchange Nucleon-Nucleon Potentials

, 1999
Off-shell aspects of the one-pion-exchange potential and their relationship to different forms of the nonstatic (subleading-order) chiral two-pion-exchange nucleon-nucleon potential are discussed.
A. Manohar, A. Stadler, B. Desplanques, C. Ordóñez, C. Ordóñez, C. Ordóñez, D. R. Phillips, E. Epelbaoum, F. B. Hildebrand, F. Coester, H. Georgi, J. Adam, Jr., J. Carlson, J. Carlson, J. L. Forest, J. L. Forest, J. L. Friar, J. L. Friar, J. L. Friar, J. L. Friar, J. L. Friar, J. L. Friar, J. L. Friar, K. A. Brueckner, M. C. M. Rentmeester, M. L. Goldberger, M. Sugawara, M. Sugawara, M. Taketani, N. Kaiser, R. Blankenbecler, R. Machleidt, S. A. Coon, S. A. Coon, S. Machida, S. Weinberg, S. Weinberg, S. Weinberg, S. Weinberg, S. Weinberg, Th. A. Rijken, U. van Kolck, V. Bernard, V. G. J. Stoks, V. Pascalutsa, Y. Nambu, Y. Tomozawa   +46 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exchange Rate Pass-Through to Consumer Prices in Nigeria [PDF]

, 2013
The increasing overdependence of Nigerian economy on imports has necessitated the need to continually examine the effect of exchange rate shocks in consumer prices.
Ogundipe, Adeyomi A., Samuel, Egbetokun
core