Results 181 to 190 of about 33,580 (237)

Hirudin Attenuates Uric Acid‐Induced Renal Tubular Injury via TNFRSF6B‐Mediated Suppression of NF‐κB Signaling

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Yingxue Zhao   +8 more
wiley   +1 more source

Tiered manufacturing of pharmaceuticals as a commercial determinant of health: Implications for medicine quality and equity. [PDF]

open access: yesPLOS Glob Public Health
Rusatira JC   +13 more
europepmc   +1 more source

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 5005-5015, August 2026.
ABSTRACT Ashwagandha ( Withania somnifera ) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale   +4 more
wiley   +1 more source

Polymers as Stabilizing Excipients for Spray-Dried Protein Formulations. [PDF]

open access: yesPharm Res
Patil CD   +8 more
europepmc   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

open access: yesSmall Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu   +3 more
wiley   +1 more source

A Copper‐Complexing Lipid Unmasks the Ethanol Hidden Within Liposomes and Highlights the Relevance of Fabrication Method on the Performance of Lipophilic Functional Molecules

open access: yesSmall Science, Volume 6, Issue 8, August 2026.
Liposomes of the same composition obtained with microfluidics (μF) and thin film hydration methods exhibit different physicochemical properties, due to residual traces of ethanol from the μF protocol. This affects the insertion of a synthetic lipophilic ligand (HIOTD) and its ability to complex Cu(II).
Leonardo Severini   +9 more
wiley   +1 more source

Impact of mono‐ or multitherapy on ocular surface health and quality of life after 5 years of follow‐up in the Glaucoma Intensive Treatment Study (GITS)

open access: yesActa Ophthalmologica, Volume 104, Issue 5, Page 535-543, August 2026.
Abstract Aim To evaluate the impact of initial mono‐ versus multitherapy on the ocular surface and related quality of life after 5 years follow‐up in the Glaucoma Intensive Treatment Study (GITS). Method The study included patients with primary open‐angle glaucoma and pseudoexfoliation glaucoma who completed 5‐year follow‐up in GITS.
Gauti Jóhannesson   +6 more
wiley   +1 more source

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