Results 201 to 210 of about 33,580 (237)
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Current Medicinal Chemistry, 2006
The therapeutical use of drugs involves the application of dosage forms, serving as carrier systems together with several excipients to deliver the active ingredient to the site of action. Drug delivery technology combines an understanding of medicinal chemistry and pharmacology with the skill of formulation, aiming the preparation of improved ...
Huba, Kalász, István, Antal
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The therapeutical use of drugs involves the application of dosage forms, serving as carrier systems together with several excipients to deliver the active ingredient to the site of action. Drug delivery technology combines an understanding of medicinal chemistry and pharmacology with the skill of formulation, aiming the preparation of improved ...
Huba, Kalász, István, Antal
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Pharmaceutical Science & Technology Today, 1999
Excipients are better known as promoters of degradation than as stabilizers of drug substances. This is not surprising. Functional groups or residues in excipients can have the propensity to interact with labile active ingredients, with attendant loss of molecular integrity or other changes in quality.
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Excipients are better known as promoters of degradation than as stabilizers of drug substances. This is not surprising. Functional groups or residues in excipients can have the propensity to interact with labile active ingredients, with attendant loss of molecular integrity or other changes in quality.
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Neonatal Network, 2000
WHY IS THE USE OF SINGLE-DOSE vials the norm in the NICU? Why is preservative-free parenteral solution standard care in the NICU? The simple response is that neonates are not just small adults. Children, especially neonates, differ from adults in their drug pharmacokinetics (absorption, distribution, metabolism, elimination).
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WHY IS THE USE OF SINGLE-DOSE vials the norm in the NICU? Why is preservative-free parenteral solution standard care in the NICU? The simple response is that neonates are not just small adults. Children, especially neonates, differ from adults in their drug pharmacokinetics (absorption, distribution, metabolism, elimination).
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American Journal of Forensic Medicine & Pathology, 2021
Abstract Crushed oral tablets, when injected intravenously, may induce a foreign body granulomatous reaction in and around pulmonary arterioles, because of the presence of filler materials (excipients). This typically presents as shortness of breath in the context of pulmonary hypertension with arteriolar dilation and centrilobular nodules on
Zarrin, Hossein-Zadeh +2 more
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Abstract Crushed oral tablets, when injected intravenously, may induce a foreign body granulomatous reaction in and around pulmonary arterioles, because of the presence of filler materials (excipients). This typically presents as shortness of breath in the context of pulmonary hypertension with arteriolar dilation and centrilobular nodules on
Zarrin, Hossein-Zadeh +2 more
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The Use of Unallowed Excipients
International Journal of Toxicology, 2003The laws governing the U.S. Food and Drug Administration (FDA) do not provide for the approval of stand-alone excipients. Current regulations do not permit the use of excipients, but allow their use. The acceptance process for excipients is slow and only recently did the FDA propose draft guidance for nonclinical studies for pharmaceutical excipients.
Marshall, Steinberg, Irwin, Silverstein
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Regulatory issues with excipients
International Journal of Pharmaceutics, 1999The history of the regulatory control of pharmaceutical ingredients is briefly reviewed. The impact of legislation, its interpretation through European and international guidelines and resulting licensing policies are discussed. The important role played by excipients in modern formulations is recognised and some examples are given of the unexpected ...
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Excipient pharmacokinetics and profiling
International Journal of Pharmaceutics, 2015Novel pharmaceutical excipients, and new derivatives of currently used excipients, are new chemical entities and as such have to go through extensive pharmacokinetic and toxicologic evaluations before they can be approved for use in pharmaceutical products.
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