Results 201 to 210 of about 76,164 (271)

Single‐Dose Pharmacokinetic Assessment of TNX‐102 SL (Cyclobenzaprine HCl Sublingual Tablets): Results From Randomized, Open‐Label Studies in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract Daily oral cyclobenzaprine hydrochloride (HCl) has provided transient benefits in fibromyalgia, a chronic pain condition. To improve this effect, we evaluated sublingual formulations designed to drive transmucosal absorption. Two open‐label studies evaluated the pharmacokinetics (PK), tolerability, and relative bioavailability of sublingual ...
Bruce L Daugherty, Bernd Meibohm, Gregory M Sullivan, Errol M Gould, Seth Lederman   +4 more
wiley   +1 more source

Monoclonal antibody formulations: a quantitative analysis of marketed products and patents. [PDF]

MAbs
Peng Y, Lyu L, Chen S, Ning B, Li C, Wu CY, Hu Y.   +6 more
europepmc   +1 more source

Results of a Phase 1 Study Assessing the Effect of CIN‐102, a Novel Formulation of the Dopamine Receptor Antagonist Domperidone Designed to Treat Gastroparesis, on Cardiac Repolarization in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract CIN‐102 is a deuterated form of domperidone in development for the treatment of acute, recurrent gastroparesis. This thorough QT study assessed the effects of CIN‐102 on cardiac repolarization in 62 healthy volunteers. In this 4‐period randomized crossover study, participants were administered single doses of 30‐mg CIN‐102 (representing ...
Mary Bond, Brian Murphy, Brendan Doran, Borje Darpo, Hongqi Xue, Leela Vrishabhendra, Jon Isaacsohn   +6 more
wiley   +1 more source

Investigation of the drug release modifying property of Pentadesma butyracea gum in diclofenac sodium matrix tablets. [PDF]

PLoS One
Archer MA, Ofori-Kwakye K, Johnson R, Attah IY, Owusu FWA, Jnr Acquah PG, Kipo SL.   +6 more
europepmc   +1 more source

A Randomized, Double‐Blind, Two‐Treatment, Two‐Period, Crossover Study Investigating the Systemic Bioavailability of a Novel Cocrystal Ubiquinol Formulation Compared with a Ubiquinone Formulation in Healthy Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract Coenzyme Q10 (CoQ10) is a naturally occurring biochemical cofactor found in all human cell membranes in two interconvertible forms: oxidized ubiquinone and reduced ubiquinol. Clinical studies indicate that different CoQ10 formulations have different absorption rates, highlighting research comparing their systemic bioavailability.
Xuefeng Mei, Bingqing Zhu, Kshitij Soni, Kishore Kasaraneni, Nirav Panchal   +4 more
wiley   +1 more source

Tocotrienols: A Review From Source to Therapeutic Applications

Food Frontiers, Volume 7, Issue 2, March 2026.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño, Nidia Casas‐Forero, Andres‐Felipe Garzón‐Méndez, Dalí‐Aleixandra Rojas‐Díaz, Mary‐Luz Olivares‐Tenorio, Hernan‐Mauricio Romero, Jesús‐Alberto García‐Núñez   +6 more
wiley   +1 more source

Spectroscopic and Chemometric Evaluation of the Stability of Timolol, Naphazoline, and Diflunisal in the Presence of Reactive Excipients Under Forced Degradation Conditions. [PDF]

Molecules
Gumieniczek A, Wesolowski M, Berecka-Rycerz A, Leyk E.   +3 more
europepmc   +1 more source

Differential Safety and Lipid Control Efficacy of β‐1,3/1,6‐Glucan Oligosaccharides and Polysaccharides Derived From Ophiocordyceps dipterigena BCC 2073 in Healthy Volunteers

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This randomized, blinded, placebo‐controlled trial uncovers the novel findings that daily supplementation with 2000 mg of β‐1,3/1,6‐glucan oligosaccharides or polysaccharides for 12 weeks is safe in healthy individuals. The oligosaccharides demonstrated superior lipid‐lowering efficacy with fewer adverse events than the polysaccharides.
Numphung Rungraung, Niramol Muangpracha, Pakkapong Phucharoenrak, Wai Prathumpai, Dunyaporn Trachootham   +4 more
wiley   +1 more source

Clinical Implications of Mechanical and Adhesive Differences Between Branded and Generic Tulobuterol Patches in Asthma Management. [PDF]

Cureus
Ishimura A, Tabayashi H, Inoue M.
europepmc   +1 more source

Screening and Identification of Triglyceride‐Lowering Lactic Acid Bacteria and Preparation of Probiotic Agents

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This study isolated and identified six lactic acid bacteria strains from various fermented foods. Through 16S rRNA sequencing, they were classified as Limosilactobacillus fermentum (PYC02, MHT02, SS01, SC03) and Weissella cibaria (PLHB02, SZ02). Their stress tolerance and safety were evaluated.
Xinglin Ran, Qian Hu, Shengdan Wei, Huizhen Long, Xu Luo, Boyu Dong, Qiuping Yao, Dequan Zhu   +7 more
wiley   +1 more source