Results 51 to 60 of about 76,164 (271)

Effects of Spray-Drying and Choice of Solid Carriers on Concentrations of Labrasol® and Transcutol® in Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS)

Molecules, 2013
Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of
Christopher Wai-Kei Lam, Tao Yi, Liang Li   +2 more
doaj   +1 more source

Study of the quantitative factors influence on pharmaco-technological properties of powder masses and tablets with plant extracts and essential oil

Фармацевтичний журнал, 2021
The available range of phytopreparations for topical use in the oral cavity does not fully meet the needs of patients as mainly medicinal plant raw materials and tinctures of domestic production represent it.
O. I. Hordiienko, T. A. Hroshovyi
doaj   +1 more source

Processing-Induced Disorder in Pharmaceutical Materials [PDF]

, 2016
This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally.
Al-Obaidi, Alkhatib, Alonzo, Bahl, Balani, Breitenbach, Brough, Brown, Cal, Cerea, Chakraborty, Chattoraj, Chieng, Clark, Cordeiro, Cui, De Beer, Descamps, DiNunzio, Dinunzio, El-Badry, Elamin, Felton, Feng, Forster, Gazzaniga, Graeser, Guns, Gupta, He, Hu, Hu, Janssens, Kang, Karmwar, Ke, Keen, Khan, Kim, Koivisto, Lai, Laitinen, Laitinen, Lang, Lauer, Luisi, Luo, Löbmann, Löbmann, Nagy, Ng, Norrman, Otte, Otte, Passerini, Patterson, Porter, Qi, Qi, Qi, Qi, Repka, Riippi, Saerens, Sammoura, Santivarangkna, Sauer, Sauer, Sill, Sollohub, Tang, Trasi, Trasi, Van den Brande, Van Eerdenbrugh, Van Eerdenbrughand, Van Melkebeke, Vehring, Weatherley, Weuts, Willart, Willart, Willart, Williams, Windbergs, Windbergs, Wojnarowska, Yang, Zamani, Zema   +89 more
core   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway

Molecular Medicine
Osteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple protective effects against tissue injury ...
Yuan Li, Jin-Yu Yang, Ma-Li Lin, Tian-Zhu Liu, Wen-Na Lu, Ying Yang, Zhong-Cheng Liu, Jian-Heng Li, Guo-Qiang Zhang, Jian-Shuang Guo   +9 more
doaj   +1 more source

Sulfafurazole dimers potentiate chemo-immunotherapy of low immunogenic breast cancer by preventing the PD-L1 exosomes secretion

Acta Pharmaceutica Sinica B
The αPD-L1 antibody-based immune checkpoint blockade therapy is still limited by the poor clinical response rate as it is mainly utilized to block surface PD-L1 on tumor cells while ignoring abundant PD-L1 exosomes secreted in the environment, causing ...
Zheng Wang, Ronghui Yin, Lin Zhang, Shiyu Li, Zhanwei Zhou, Minjie Sun   +5 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULES WITH OIL OF VIBURNUM

Фармация и фармакология (Пятигорск), 2015
The article presents results of a study of excipients selection to create a capsule. We have presented an obtainment technology for the gelatin capsules with Viburnum oil.
A. V. Brazhenko, Y. V. Shikova, Z. R. Nova   +2 more
doaj   +1 more source

Activity of Experimental Mouthwashes and Gels Containing DNA-RNA and Bioactive Molecules against the Oxidative Stress of Oral Soft Tissues: The Importance of Formulations. A Bioreactor-Based Reconstituted Human Oral Epithelium Model

Molecules, 2021
Background: DNA-RNA compounds have shown promising protection against cell oxidative stress. This study aimed to assess the cytotoxicity, protective, or preventive effect of different experimental formulations on oral epithelia’s oxidative stress in ...
Andrei C. Ionescu, Elena Vezzoli, Vincenzo Conte, Patrizia Sartori, Patrizia Procacci, Eugenio Brambilla   +5 more
doaj   +1 more source

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press [PDF]

, 2014
Context: Tableting is a complex process due to the large number of process parameters that can be varied. Knowledge and understanding of the influence of these parameters on the final product quality is of great importance for the industry, allowing ...
De Beer, Thomas, Peeters, Elisabeth, Remon, Jean Paul, Vervaet, Chris   +3 more
core   +1 more source