Results 141 to 150 of about 151,712 (215)

Stroke is associated with temporally ordered neuromotor dysfunction from cortex to muscle in a translational mouse model. [PDF]

J Cereb Blood Flow Metab
Ketabforoush A, Wang M, Oberoi V, Brennan C, Meier G, Viteri J, Snyder H, Suleiman L, Pathak I, Ma L, Goswami V, Castoro R, Arnold WD.   +12 more
europepmc   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Four‐Dimensional Electrochemiluminescence Microscopy Enables Depth‐Resolved Imaging of Single, Living Spheroids

Angewandte Chemie, EarlyView.
A hybrid “confocal” electrochemiluminescence (ECL) microscopy combines depth‐resolved and time‐resolved imaging to visualize ECL processes across three spatial dimensions and time. By exploiting sluggish coreactant kinetics at ITO electrodes, homogeneous redox propagation enables depth‐resolved, single‐cell resolution mapping of living multicellular ...
Elisa D'Arrigo, Vanshika Gupta, Bertrand Goudeau, Jeffrey E. Dick, Neso Sojic   +4 more
wiley   +2 more sources

Motor cortex rTMS modulates adult ocular dominance plasticity. [PDF]

Cereb Cortex
Sarı İD, Papakosta V, Corominas Teruel X, Willis H, Valero-Cabré A, Lunghi C.   +5 more
europepmc   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Locke's View of the Hard Problem of Consciousness and Its Implications for Neuroscience and Computer Science

Frontiers in Psychology, 2017
John E. Lisman
doaj   +1 more source

K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses. [PDF]

Front Pharmacol
Gilbert N, Jeanne K, Li A, Lorivel T, Chatelain FC, Lesage F, Bichet D.   +6 more
europepmc   +1 more source

Piezo1 in Peripheral and Central Sensitisation: Implications for Chronic Pain. [PDF]

Bioengineering (Basel)
Kopach O.
europepmc   +1 more source

Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain. [PDF]

Front Pain Res (Lausanne)
Vicente-Mampel J, Mampel-Ariño M, Vicente-Mampel C, Belda-Antolí M, Martinez-Soler M, Alonso-Martín M.   +5 more
europepmc   +1 more source