Results 81 to 90 of about 1,712,147 (281)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Fusion excitation function revisited

, 2012
We report on a comprehensive systematics of fusion-evaporation and/or fusion-fission cross sections for a very large variety of systems over an energy range 4-155 A.MeV. Scaled by the reaction cross sections, fusion cross sections do not show a universal
, Basrak Z, Bass R, Beck C, Bisquer E, Chbihi A, Eudes Ph, F Sébille, G Royer, M Zorić, Ph Eudes, Tripathi A, V de la Mota, Vigdor S E, Z Basrak   +14 more
core   +3 more sources

Opposing effects of intrinsic conductance and correlated synaptic input on Vm-fluctuations during network activity

Frontiers in Computational Neuroscience, 2012
Neurons often receive massive concurrent bombardment of synaptic inhibition and excitation during functional network activity. This increases membrane conductance and causes fluctuations in membrane potential (Vm) and spike timing.
Jens eKolind, Jorn eHounsgaard, Rune W. Berg   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Accuracy of B(E2; 0+ -> 2+) transition rates from intermediate-energy Coulomb excitation experiments

, 2005
The method of intermediate-energy Coulomb excitation has been widely used to determine absolute B(E2; 0+ -> 2+) quadrupole excitation strengths in exotic nuclei with even numbers of protons and neutrons. Transition rates measured with intermediate-energy
A. B. McDonald, A. Bohr, A. Buerger, A. Gade, D. B. Fossan, D. S. Andreev, H. Morinaga, J. M. Cook, K. Alder, O. Hausser, T. Glasmacher, V. M. Khvastunov   +11 more
core   +1 more source

Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations

Children
Infantile spasms are common in Down Syndrome (DS), but the mechanisms by which DS predisposes to this devastating epilepsy syndrome are unclear.
Carl E. Stafstrom, Li-Rong Shao
doaj   +1 more source

Excitation Number: Characterizing Multiply Excited States

Journal of Chemical Theory and Computation, 2017
How many electrons are excited in an electronic transition? In this Letter, we introduce the excitation number η to answer this question when the initial and final states are each modeled by a single-determinant wave function. We show that calculated η values lie close to positive integers, leading to unambiguous assignments of the number of excited ...
Giuseppe M. J. Barca, Andrew T. B. Gilbert, Peter M. W. Gill   +2 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Complex Dynamics of Propagating Waves in a Two-Dimensional Neural Field

Frontiers in Computational Neuroscience, 2019
Propagating waves with complex dynamics have been widely observed in neural population activity. To understand their formation mechanisms, we investigate a type of two-dimensional neural field model by systematically varying its recurrent excitatory and ...
Daniel Naoumenko, Pulin Gong, Pulin Gong
doaj   +1 more source