Results 1 to 10 of about 37,595 (283)
Interaction of Excitatory Amino Acid Agonists with Cortical Afterdischarges in Developing Rats [PDF]
Epilepsia, 2002 Summary: Purpose: To determine the role of excitatory amino acids (EAAs) in genesis of two types of epileptic afterdischarges.Methods: Cortical stimulation and recording electrodes were implanted in 12‐, 18‐, and 25‐day‐old rats. Epileptic afterdischarges were induced by rhythmic stimulation of sensorimotor cortex.
Pavel Mareš +2 more
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Agonists, antagonists and modulators of excitatory amino acid receptors in the guinea‐pig myenteric plexus [PDF]
British Journal of Pharmacology, 1988 The receptors for glutamic acid (L‐Glu) present in the guinea‐pig myenteric plexus‐ileal longitudinal muscle preparation have been studied by measuring the muscle contraction induced by numerous putative endogenous agonists acting at these receptors.
Simona Luzzi +4 more
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Mixed‐agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
The Journal of Physiology, 1984 Neurones from the ventral half of mouse embryo spinal cord were grown in tissue culture and voltage clamped with two micro‐electrodes. The current‐voltage relation of responses evoked by brief pressure applications of excitatory amino acids was examined over a membrane potential range of ‐100 to +70 mV.
Mark L. Mayer, Gary L. Westbrook
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Journal of Medicinal Chemistry, 1996 The homologous series of acidic amino acids, ranging from aspartic acid (1) to 2-aminosuberic acid (5), and the corresponding series of 3-isoxazolol bioisosteres of these amino acids, ranging from (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA, 6) to (RS)-2-amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid (10), were tested as ...
Hans Bräuner‐Osborne +6 more
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A new type of agonist for excitatory amino acid receptors
Japanese Journal of Pharmacology, 1990 Michiko Ishida, Haruhiko Shinozaki
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Biomolecules, 2022 L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS). Its associated receptors localized on neuronal and non-neuronal cells mediate rapid excitatory synaptic transmission in the CNS and regulate a wide range of ...
Elena A. Golubeva +3 more
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Plants, 2022 Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz +7 more
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Molecules, 2020 This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and neodysiherbaine A, known as potent agonists of one of subtypes of glutamate receptors, the so-called kainate ...
Valentin A. Stonik, Inna V. Stonik
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Neuroprotection, excitotoxicicity and nmda antagonists [PDF]
Arquivos de Neuro-Psiquiatria, 2000 PURPOSE: To analyze the main aspects of neuroprotection and excitotoxicity. DISCUSSION: This is a significant theory on the pathophysiology of cerebral ischemia; it is based on the release of excitatory aminoacid (EAA), mainly glutamate.
RUBENS JOSÉ GAGLIARDI
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Cell & Bioscience, 2023 Background Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked to the protein α-synuclein (α-syn) including Parkinson’s disease (PD).
Altair Brito Dos Santos +7 more
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