Results 151 to 160 of about 37,595 (283)

Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta2‐Adrenergic Agonist

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individuals unable to engage in physical activity. Because beta2‐adrenergic stimulation induces muscle growth without mechanical load, we assessed muscle ...
Søren Jessen, Andrea Di Credico, Roger Moreno‐Justicia, Lukas Moesgaard, Anders Lemminger, Ben Stocks, Angela Di Baldassarre, Jens Bangsbo, Atul S. Deshmukh, Morten Hostrup   +9 more
wiley   +1 more source

Metabotropic glutamate receptors: Allosteric structural modulation and new treatments for anxiety disorders. [PDF]

Neurosciences (Riyadh)
Zakari MO.
europepmc   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
wiley   +1 more source

The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity. [PDF]

Sci Rep
Khadrawy YA, Khoder NM, El-Gizawy MM, Hosny EN, Sawie HG, Elkholy NS, Amer HM, Ezz HSA.   +7 more
europepmc   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Changes in Metabolites and Microbial Communities in Follicular Fluid Associated With Ovarian Function in Patients With Polycystic Ovary Syndrome

MedComm, Volume 7, Issue 2, February 2026.
Based on the integrated analysis of follicular fluid metabolites and microbial communities in patients with PCOS, this study reveals significant dysregulation in the follicular microenvironment. Key metabolites including D‐glucose and 25‐hydroxycholesterol show marked alterations, while microbial communities such as Alicyclobacillus and Terrimonas ...
Manfei Si, Sen Yan, Shu Ding, Rui Liu, Xianglei Xiong, Jie Qiao, Xinyu Qi   +6 more
wiley   +1 more source

The Involvement of the Endocannabinoid, Glutamatergic, and GABAergic Systems in PTSD. [PDF]

Int J Mol Sci
Grzesińska AD.
europepmc   +1 more source

Beyond olfaction: New insights into human odorant binding proteins

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Until today, the exact function of mammalian odorant binding proteins (OBPs) remains a topic of debate. Although their main established function lacks direct evidence in human olfaction, OBPs are traditionally believed to act as odorant transporters in the olfactory sense. Now, available RNA‐seq and proteomics data identified the expression of
Mifen Chen, Soufyan Lakbir, Mihyeon Jeon, Vojta Mazur, Sanne Abeln, Halima Mouhib   +5 more
wiley   +1 more source

Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors. [PDF]

Pharmaceuticals (Basel)
Rosas-Arellano A.
europepmc   +1 more source

Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin, Moeka Sasazawa, James Byrnes, Mark E. Bowen   +3 more
wiley   +1 more source